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D-fructose 6-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

15 compounds within 3 steps: 2 in 1, 4 in 2, 9 in 3

Does it reach a compound?

One step

D-glucosamine 6-phosphateReach from here →
1. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
Catalysed by GFPT2, GFPT1
D-mannose 6-phosphateReach from here →
1. D-mannose 6-phosphate = D-fructose 6-phosphate
Catalysed by MPI

Two steps

2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactoneReach from here →
1. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
2. D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + NADPH + 2 H(+)
Catalysed by GFPT2, GFPT1, H6PD
N-acetyl-D-glucosamine 6-phosphateReach from here →
1. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
2. D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)
Catalysed by GFPT2, GFPT1, GNPNAT1One of 2 routes

Three steps

alpha-D-glucosamine 6-phosphateReach from here →
Catalysed by GFPT2, GFPT1, GNPNAT1, CEMP1 and 1 morecytosol
NAADPHReach from here →

alpha-D-mannose 1-phosphateReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
alpha-D-mannose 1-phosphate = D-mannose 6-phosphate

Catalysed by MPI, PMM2, PMM1

D-glucose 6-phosphateReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
D-glucose 6-phosphate = D-mannose 6-phosphate

Catalysed by MPI, GPI

Catalysed by MPI, GPI, G6PD

acetateReach from here →

D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)
N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

Catalysed by GFPT2, GFPT1, GNPNAT1, CEMP1 and 1 morecytosolOne of 2 routes

D-glucoseReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)

Catalysed by MPI, GPI, ADPGKOne of 2 routes

N-acetyl-alpha-D-glucosamine 1-phosphateReach from here →

D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)
N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

Catalysed by GFPT2, GFPT1, GNPNAT1, PGM3

6-phospho-D-glucono-1,5-lactoneReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)

Catalysed by MPI, GPI, H6PD, G6PDOne of 3 routes

(2R)-3-phosphoglycerateReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = alpha-D-mannose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)

Catalysed by MPI, PMM2, PMM1, PGM2L1

1D-myo-inositol 3-phosphateReach from here →

D-mannose 6-phosphate = D-fructose 6-phosphate
D-glucose 6-phosphate = D-mannose 6-phosphate
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate

Catalysed by MPI, GPI, ISYNA1

2-acetamido-2-deoxy-D-glucopyranose 1-phosphateReach from here →

D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)
phosphoglucomutase (N-acetylglucosamine-6-phosphate)

Catalysed by GFPT2, GFPT1, GNPNAT1, PGM3cytosol