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Proteins/UNIPROT:Q9UMR5
Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate..
[Isoform 2]: Catalytically inactive due to lack of active site His-283..
Function from UniProtKB (Q9UMR5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
45 statements
45 statements · 5 reference databases · Subject: PPT2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
4 reactions
water+palmitoyl-CoACHEBI:1146900+proton+hexadecanoic acid
Catalysed by ACOT7 or ACOT2 or PPT1 or BAAT or ACOT4 or ACOT1 or ACOT6 or PPT2 or EGFL8
Reaction pageLeft to rightBalancedEC 3.1.2.2, 3.1.2.22peroxisome
Human-GEM MAR00709CC BY 4.0Reference data
3 names
Resolves to: PPT2
arachidonoyl-CoA+water(5Z,8Z,11Z,14Z)-eicosatetraenoate+CHEBI:1146900+proton
Catalysed by ACOT7 or ACOT2 or PPT1 or BAAT or ACOT4 or ACOT1 or ACOT6 or PPT2 or EGFL8
Reaction pageLeft to rightBalancedEC 3.1.2.2, 3.1.2.22peroxisome
Human-GEM MAR03015CC BY 4.0Reference data
hexadecanoyl-CoA+waterhexadecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or PLA2G6 or ACAA2 or ACOT2 or PPT1 or BAAT or THEM4 or MBLAC2 or ACOT1 or THEM5 or ACOT4 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16645CC BY 4.0Reference data
S-hexadecanoyl-N-acetylcysteamine+waterN-acetylcysteamine+hexadecanoate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:84099CC BY 4.0Reference data