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Proteins/UNIPROT:P50897
Has thioesterase activity against fatty acid thioesters with 14 -18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins. In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine..
Function from UniProtKB (P50897), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
251 statements
251 statements · 7 reference databases · Subject: PPT1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
7 reactions
water+palmitoyl-CoACHEBI:1146900+proton+hexadecanoic acid
Catalysed by ACOT7 or ACOT2 or PPT1 or BAAT or ACOT4 or ACOT1 or ACOT6 or PPT2 or EGFL8
Reaction pageLeft to rightBalancedEC 3.1.2.2, 3.1.2.22peroxisome
Human-GEM MAR00709CC BY 4.0Reference data
4 names
Resolves to: PPT1
arachidonoyl-CoA+water(5Z,8Z,11Z,14Z)-eicosatetraenoate+CHEBI:1146900+proton
Catalysed by ACOT7 or ACOT2 or PPT1 or BAAT or ACOT4 or ACOT1 or ACOT6 or PPT2 or EGFL8
Reaction pageLeft to rightBalancedEC 3.1.2.2, 3.1.2.22peroxisome
Human-GEM MAR03015CC BY 4.0Reference data
water+MAM02918cMAM00200c+proton+hexadecanoic acid
Reaction pageLeft to rightBalance undeterminableEC 3.1.2.22cytosol
Human-GEM MAR09499CC BY 4.0Reference data
hexadecanoyl-CoA+waterhexadecanoate+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ACOT8 or PLA2G6 or ACAA2 or ACOT2 or PPT1 or BAAT or THEM4 or MBLAC2 or ACOT1 or THEM5 or ACOT4 and 5 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16645CC BY 4.0Reference data
S-hexadecanoyl-L-cysteinyl-[protein]+waterL-cysteinyl-[protein]+hexadecanoate+hydron
Catalysed by CLN5 or LYPLA1 or LYPLA2 or PPT1 or ABHD17B or LYPLAL1 or DESI1 or ABHD17C or CPT1C or ABHD17A or DESI2 or ABHD10
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19233CC BY 4.0Reference data
S-hexadecanoyl-N-acetylcysteamine+waterN-acetylcysteamine+hexadecanoate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:84099CC BY 4.0Reference data
S-hexadecanoyl-N-acetylcysteine methyl ester+waterN-acetylcysteine methyl ester+hexadecanoate+hydron
Catalysed by PPT1
Reaction pageDirection not assertedBalanced
Rhea RHEA:84103CC BY 4.0Reference data