Loading the page.
Proteins/UNIPROT:Q08477
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). May play a role in inactivation of pro-inflammatory and anti-inflammatory oxylipins during the resolution of inflammation..
[Isoform CYP4F3A]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of oxylipins in myeloid cells, displaying higher affinity for arachidonate metabolite leukotriene B4 (LTB4). Inactivates LTB4 via three successive oxidative transformations to 20-hydroxy-LTB4, then to 20-oxo-LTB4 and to 20-carboxy-LTB4. Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate. Omega-hydroxylates monohydroxy polyunsaturated fatty acids (PUFAs), including hydroxyeicosatetraenoates (HETEs) and hydroxyeicosapentaenoates (HEPEs), to dihydroxy compounds. Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening. Has low hydroxylase activity toward PUFAs..
[Isoform CYP4F3B]: Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of polyunsaturated fatty acids (PUFAs). Participates in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Has high omega-hydroxylase activity toward other PUFAs, including eicosatrienoic acid (ETA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of PUFAs with lower efficiency. Contributes to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid and hexacosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acids, thereby initiating chain shortening. Omega-hydroxylates long-chain 3-hydroxy fatty acids, likely initiating the oxidative conversion to the corresponding 3-hydroxydicarboxylic fatty acids. Has omega-hydroxylase activity toward long-chain fatty acid epoxides with preference for 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate (EET) and 9,10-epoxyoctadecanoate..
Function from UniProtKB (Q08477), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · metabolized by
1 compound
1 compound.
0 reported routes1 assembled route
55 statements
55 statements · 7 reference databases · Subject: CYP4F3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
84 reactions
8 names
Resolves to: CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR00981CC BY 4.0Reference data
proton+MAM02096c+NADPH(4-)+dioxygenMAM00598c+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR01059CC BY 4.0Reference data
proton+MAM02096r+NADPH(4-)+dioxygenMAM00598r+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94endoplasmic reticulum
Human-GEM MAR01061CC BY 4.0Reference data
MAM00307c+proton+NADPH(4-)+dioxygenMAM00318c+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR01071CC BY 4.0Reference data
MAM00307r+proton+NADPH(4-)+dioxygenMAM00318r+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94endoplasmic reticulum
Human-GEM MAR01072CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADPH(4-)+dioxygenMAM00331c+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR01107CC BY 4.0Reference data
12-oxo-leukotriene B4+proton+NADPH(4-)+dioxygenMAM00331r+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94endoplasmic reticulum
Human-GEM MAR01108CC BY 4.0Reference data
MAM00331c+proton+NADPH(4-)+dioxygenMAM00330c+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR01109CC BY 4.0Reference data
MAM00331r+proton+NADPH(4-)+dioxygenMAM00330r+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94endoplasmic reticulum
Human-GEM MAR01110CC BY 4.0Reference data
MAM00330c+proton+NADPH(4-)+dioxygenMAM00332c+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR01111CC BY 4.0Reference data