3,5-diiodo-L-tyrosine

Three steps

• kinetensinReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. Chymase

  Catalysed by IYD, PAH, CMA1extracellular space

• an N-(fatty acyl)-glycineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by IYD, AADAT, GLYATL2

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by IYD, AADAT, GLYATL2

• cholineReach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC5A7extracellular space, cytosol

• acetylcholineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• acetylpyruvateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• all-trans-retinoic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by TPO, SDS, SDSL, SRR and 6 morecytosol, extracellular spaceOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by IYD, PAHcytosol

• CHEBI:15570Reach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by IYD, AADAT, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• (S)-malateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosolOne of 2 routes

• L-leucineReach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC6A14extracellular space, cytosolOne of 15 routes

• CHEBI:15611Reach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by IYD, AADAT, GNMTcytosol

• CHEBI:15650Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and leukotriene E4 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• CHEBI:15699Reach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of homoserine and phenylalanine (cytosol to extracellular)

  Catalysed by IYD, PAH, SLC7A5extracellular space, cytosolOne of 7 routes

• betaine aldehydeReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. choline + A = betaine aldehyde + AH2

  Catalysed by TPO, DIO1, DIO3, CHDHcytosol

• CHEBI:15765Reach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + O2 = L-dopaquinone + H2O
  3. 2-carboxy-2,3-dihydro-5,6-dihydroxyindole to L-dopa conversion

  Catalysed by IYD, TYRcytosolOne of 2 routes

• bromideReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by TPO, SLCO1A2, SLCO1B3, MGST3 and 16 morecytosol, extracellular spaceOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by IYD, SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosol

• CHEBI:15971Reach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC6A14extracellular space, cytosolOne of 5 routes

• homogentisateReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  3. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by IYD, TAT, HPDcytosolOne of 2 routes

• sulfateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. aryl sulfotransferase (PAPS)
  3. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)

  Catalysed by TPO, SULT1A3, SULT1A4, SULT1A1 and 2 morecytosolOne of 4 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol, mitochondrial matrix

• L-cystineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by IYD, SLC7A13inner side of the membrane, outer side of the membraneOne of 2 routes

• lithocholic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• L-citrullineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. transport of citrulline and phenylalanine (cytosol to extracellular)

  Catalysed by IYD, PAH, SLC7A6extracellular space, cytosolOne of 3 routes

• L-valineReach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC6A14extracellular space, cytosolOne of 13 routes

• oxaloacetateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol, mitochondrial matrixOne of 9 routes

• L-arginineReach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC6A14extracellular space, cytosolOne of 8 routes

• CHEBI:16523Reach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by IYD, AADAT, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. PROTEIN_BS

  Catalysed by IYD, PAHcytosolOne of 3 routes

• 2-phenylacetamideReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by IYD, PAH, EPXcytosol

• (S)-lactateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by TPO, SDS, SDSL, SRR and 5 morecytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by IYD, PAH, CNDP2

• 2-oxobutanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• 2-oxoglutaramateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosolOne of 2 routes

• formaldehydeReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2

  Catalysed by TPO, DIO1, DIO3, KDM1A and 1 morecytosolOne of 3 routes

• 3-fumarylpyruvateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• CHEBI:16857Reach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by IYD, SLC26A4, SLC6A14extracellular space, cytosolOne of 9 routes

• glyoxylic acidReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by IYD, AADAT, DAOperoxisome

• N-acetyl-L-aspartateReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by IYD, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• bilirubin IXalphaReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of bilirubin and GSH (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• oxalic acidReach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC26A6extracellular space, cytosol

• (R)-3-hydroxybutyric acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by TPO, SDS, SDSL, SRR and 6 morecytosol, extracellular spaceOne of 2 routes

• taurolithocholateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. transport of GSH and taurolithocholate (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• 3-hydroxypyruvateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• L-isoleucineReach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by IYD, SLC26A4, SLC6A14extracellular space, cytosolOne of 11 routes

• CHEBI:17203Reach from here →
  1. 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by IYD, SLC26A4, CLTRN, SLC6A20extracellular space, cytosolOne of 8 routes

• CHEBI:17208Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular space

• (S)-4-hydroxymandelateReach from here →
  1. 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + 2 NADPH + H(+)
  2. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  3. 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2

  Catalysed by IYD, TAT, HPDL

• homocysteineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and thyroxine (cytosol to extracellular)
  3. Formation of Homocystine

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular space