a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol

Three steps

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by PIGL, CYP17A1endoplasmic reticulum, cytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PIGL, PIGW, ACAA1, SCP2 and 1 moreendoplasmic reticulum, peroxisomeOne of 7 routes

• chlorine(.)Reach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and formate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A1 and 1 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• putrescineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N-acetylputrescine + H2O = putrescine + acetate
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by PIGL, HDAC10endoplasmic reticulum

• 3-oxopropanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• a phenolReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. a phenyl acetate + H2O = a phenol + acetate + H(+)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by PIGL, PON1, PON2, PON3endoplasmic reticulum

• D-serineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• (R)-lactic acidReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A6 and 4 moreendoplasmic reticulum, extracellular space, cytosol

• 2-iminopropanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• phosphoenolpyruvic acidReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 4 moreendoplasmic reticulum, extracellular space, cytosol

• 13-cis-retinalReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A7 and 2 moreendoplasmic reticulum, extracellular space, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• L-ornithineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N2-Acetyl-L-ornithine amidohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by PIGL, ACY1endoplasmic reticulum, cytosol

• taurineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PIGL, PIGW, BAATendoplasmic reticulum, cytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• acetoacetyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A6 and 3 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PIGL, PIGW, GLYAT, GLYATL2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PIGL, PIGW, ALDH6A1endoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PIGL, PIGWendoplasmic reticulum, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PIGL, PIGW, ACP2endoplasmic reticulum, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PIGL, PIGWendoplasmic reticulum, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PIGL, PIGW, ACAA1, MYO5Bendoplasmic reticulum, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PIGL, PIGW, ACSM4, ACSM1 and 4 moreendoplasmic reticulum, cytosolOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Production of Glutaryl Carnitine

  Catalysed by PIGL, PIGW, CPT1A, CPT1C and 1 moreendoplasmic reticulum, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PIGL, PIGW, SUCLG1, SUCLG2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 6 moreendoplasmic reticulum, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PIGL, PIGW, CROTendoplasmic reticulum, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. phytanate-CoA ligase

  Catalysed by PIGL, PIGWendoplasmic reticulum, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PIGL, PIGW, SLC27A2, ACSL4 and 5 moreendoplasmic reticulum, cytosolOne of 15 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol

• sphing-4-enineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PIGL, PIGW, ASAH1, ACER2 and 2 moreendoplasmic reticulum, Golgi apparatusOne of 3 routes

• N-acetyl-alpha-D-glucosamine 1-phosphateReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

  Catalysed by PIGL, AMDHD2, PGM3endoplasmic reticulum

• spermidineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by PIGL, PIGW, SAT1, SAT2endoplasmic reticulum, cytosolOne of 5 routes

• L-methionineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by PIGL, PIGW, NAGSendoplasmic reticulum, mitochondrial matrixOne of 2 routes

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by PIGL, ASAH1, PLA2G15endoplasmic reticulum

• L-alanineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by PIGL, PIGWendoplasmic reticulum, mitochondrial matrixOne of 19 routes

• L-asparagineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by PIGL, PIGW, NAGSendoplasmic reticulum, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by PIGL, PIGW, NAGSendoplasmic reticulum, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by PIGL, ASAH1, PLA2G15endoplasmic reticulum

• an acyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PIGL, PIGW, ASAH1, ACER2 and 2 moreendoplasmic reticulum, Golgi apparatusOne of 2 routes

• cadaverineReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. N-acetylcadaverine + H2O = cadaverine + acetate
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by PIGL, HDAC10endoplasmic reticulum

• (3Z)-dodecenoyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. phosphatidylinositol glycan anchor biosynthesis class W
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by PIGL, PIGW, HADHA, ACAA2 and 1 moreendoplasmic reticulum, mitochondrial matrixOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. phosphatidylinositol glycan anchor biosynthesis class L
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by PIGL, SLC16A4, SLC16A5, SLC16A3 and 3 moreendoplasmic reticulum, extracellular space, cytosol