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Proteins/UNIPROT:Q15165
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis..
Function from UniProtKB (Q15165), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
208 statements
208 statements · 8 reference databases · Subject: PON2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
water+L-homocysteine thiolactoneproton+homocysteine
Catalysed by PON1 or PON3 or PON2
Reaction pageReversibleBalancedEC 3.1.1.2cytosol
Human-GEM MAR03920CC BY 4.0Reference data
a phenyl acetate+watera phenol+acetate+hydron
Catalysed by PON1
4 names
Resolves to: PON2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:17309CC BY 4.0Reference data
CHEBI:55474+waterCHEBI:58921+hydron
Catalysed by PON1 or PON2 or PON3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:22576CC BY 4.0Reference data