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Proteins/UNIPROT:Q7Z7B1

PIGW

Protein·UNIPROT:Q7Z7B1Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

Open in the graph

Acyltransferase that catalyzes the acyl transfer from an acyl-CoA at the 2-OH position of the inositol ring of a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl phosphatidylinositol, GlcN-PI) to generate a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) and participates in the fourth step of GPI-anchor biosynthesis (By similarity). Required for the transport of GPI-anchored proteins to the plasma membrane. Acylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity)..

Function from UniProtKB (Q7Z7B1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency has a germline basis in PIGWDiseaseGenCC HGNC:23213|MONDO:0012465Inferred only
hyperphosphatasia with intellectual disability syndrome 5 has a germline basis in PIGWDiseaseGenCC HGNC:23213|MONDO:0014457Inferred only
hyperphosphatasia-intellectual disability syndrome has a germline basis in PIGWDiseaseGenCC HGNC:23213|MONDO:0016596Inferred only

Statements

21 statements

21 statements · 5 reference databases · Subject: PIGW · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

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CABS1 covaries with PIGWProteinHetionet hetionet:covaries:284098-85438Inferred only
OR13C4 covaries with PIGWProteinHetionet hetionet:covaries:138804-284098Inferred only
ZNF197 covaries with PIGWProteinHetionet hetionet:covaries:10168-284098Inferred only
ZNF331 covaries with PIGWProteinHetionet hetionet:covaries:284098-55422Inferred only
ZSCAN21 covaries with PIGWProteinHetionet hetionet:covaries:284098-7589Inferred only
ZSCAN22 covaries with PIGWProteinHetionet hetionet:covaries:284098-342945Inferred only
UBC interacts with PIGWProteinHetionet hetionet:interacts:284098-7316Inferred only
PIGW participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only
PIGW participates in Glycosylphosphatidyl inositol anchor pathwayPathwayWikiPathways WP5505Inferred only
PIGW participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PIGW participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
PIGW participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Show the remaining 9

PIGW participates in Synthesis of glycosylphosphatidylinositol (GPI)PathwayReactome R-HSA-162710Inferred only
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol is a substrate of PIGWCompoundHuman-GEM MAR07187Inferred only
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol is a substrate of PIGWCompoundRhea RHEA:83759Inferred only
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol is a substrate of PIGWCompoundRhea RHEA:60496Inferred only
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol is a substrate of PIGWCompoundHuman-GEM MAR08381Inferred only
a fatty acyl-CoA is a substrate of PIGWCompoundRhea RHEA:60496Inferred only
hexadecanoyl-CoA is a substrate of PIGWCompoundRhea RHEA:83759Inferred only
palmitoyl-CoA is a substrate of PIGWCompoundHuman-GEM MAR07187Inferred only
palmitoyl-CoA is a substrate of PIGWCompoundHuman-GEM MAR08381Inferred only

Reactions

4 reactions

a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+palmitoyl-CoACHEBI:1146900+MAM01964r
Catalysed by PIGW
Reaction pageLeft to rightBalance undeterminableEC 2.3.-.-endoplasmic reticulum
Human-GEM MAR07187CC BY 4.0Reference data
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+palmitoyl-CoACHEBI:1146900+MAM01964c
Catalysed by PIGW
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: PIGW

Also called: GlcN-PI-acyltransferasePhosphatidylinositol-glycan biosynthesis class W proteinPIG-W

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EC 2.3.-.-

cytosol

Human-GEM MAR08381CC BY 4.0Reference data

a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+a fatty acyl-CoAa 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+coenzyme A(4-)

Catalysed by PIGW

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:60496CC BY 4.0Reference data

a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+hexadecanoyl-CoAa 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+coenzyme A(4-)

Catalysed by PIGW

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:83759CC BY 4.0Reference data