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Proteins/UNIPROT:Q9Y2B2

PIGL

Protein·UNIPROT:Q9Y2B2N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Open in the graph

Catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol..

Function from UniProtKB (Q9Y2B2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

CHIME syndrome has a germline basis in PIGLDiseaseGenCC HGNC:8966|MONDO:0010221Inferred only
hyperphosphatasia-intellectual disability syndrome has a germline basis in PIGLDiseaseGenCC HGNC:8966|MONDO:0016596Inferred only
syndromic intellectual disability has a germline basis in PIGLDiseaseGenCC HGNC:8966|MONDO:0000508Inferred only

Statements

10 statements

10 statements · 5 reference databases · Subject: PIGL · Sources: Bgee, Human-GEM, Reactome, Rhea, WikiPathways

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PIGL is expressed in mucosa of stomachAnatomyBgee ENSG00000108474Inferred only
PIGL is expressed in right fallopian tubeAnatomyBgee ENSG00000108474Inferred only
PIGL participates in Glycosylphosphatidyl inositol anchor pathwayPathwayWikiPathways WP5505Inferred only
PIGL participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PIGL participates in Post-translational modification: synthesis of GPI-anchored proteinsPathwayReactome R-HSA-163125Inferred only
PIGL participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
PIGL participates in Synthesis of glycosylphosphatidylinositol (GPI)PathwayReactome R-HSA-162710Inferred only
a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol is a substrate of PIGLCompoundHuman-GEM MAR07186Inferred only
a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol is a substrate of PIGLCompoundRhea RHEA:11660Inferred only
a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol is a substrate of PIGLCompoundHuman-GEM MAR08380Inferred only

Reactions

3 reactions

water+a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositola 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+acetate
Catalysed by PIGL
Reaction pageLeft to rightBalance undeterminableEC 3.5.1.89endoplasmic reticulum
Human-GEM MAR07186CC BY 4.0Reference data
water+a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositola 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+acetate
Catalysed by

Other names

2 names

Resolves to: PIGL

Also called: Phosphatidylinositol-glycan biosynthesis class L proteinPIG-L

← Every protein Find it in the graph →

Reaction pageLeft to rightBalance undeterminableEC 3.5.1.89cytosol

Human-GEM MAR08380CC BY 4.0Reference data

a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+watera 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol+acetate

Catalysed by PIGL

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:11660CC BY 4.0Reference data