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Proteins/UNIPROT:Q15166
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents..
Function from UniProtKB (Q15166), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
143 statements
143 statements · 9 reference databases · Subject: PON3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
17 reactions
water+L-homocysteine thiolactoneproton+homocysteine
Catalysed by PON1 or PON3 or PON2
Reaction pageReversibleBalancedEC 3.1.1.2cytosol
Human-GEM MAR03920CC BY 4.0Reference data
water+MAM03179cproton+MAM03177c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2
Human-GEM MAR12343CC BY 4.0Reference data
water+MAM03228cproton+MAM03229c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12369CC BY 4.0Reference data
water+MAM03239cproton+MAM03240c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12379CC BY 4.0Reference data
water+MAM03272cproton+MAM03271c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12393CC BY 4.0Reference data
water+MAM03292cproton+MAM03293c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12425CC BY 4.0Reference data
water+MAM03296cproton+MAM03297c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12432CC BY 4.0Reference data
water+MAM03298cproton+MAM03299c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12434CC BY 4.0Reference data
water+MAM03300cproton+MAM03301c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12437CC BY 4.0Reference data
water+MAM03303cproton+MAM03302c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12440CC BY 4.0Reference data
water+MAM03479cproton+MAM03476c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12511CC BY 4.0Reference data
water+MAM03736cproton+MAM03737c
Catalysed by PON3
Reaction pageLeft to rightBalancedEC 3.1.1.2cytosol
Human-GEM MAR12775CC BY 4.0Reference data