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Proteins/UNIPROT:P27169
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation..
Function from UniProtKB (P27169), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 8 reference databases · Subject: PON1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
water+L-homocysteine thiolactoneproton+homocysteine
Catalysed by PON1 or PON3 or PON2
Reaction pageReversibleBalancedEC 3.1.1.2cytosol
Human-GEM MAR03920CC BY 4.0Reference data
a phenyl acetate+watera phenol+acetate+hydron
Catalysed by PON1
6 names
Resolves to: PON1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:17309CC BY 4.0Reference data
CHEBI:55474+waterCHEBI:58921+hydron
Catalysed by PON1 or PON2 or PON3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:22576CC BY 4.0Reference data