(5-hydroxyindol-3-yl)acetaldehyde

Three steps

• 3,3',5-triiodo-L-thyronineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by MAOA, AANAT, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by MAOA, AANAT, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by MAOA, AANATcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by MAOA, AANAT, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by MAOA, AANATcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by MAOA, AANAT, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by MAOA, AANAT, ACSM4, ACSM1 and 4 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by MAOA, AANAT, CPT1A, CPT1C and 1 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by MAOA, AANAT, SUCLG1, SUCLG2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 6 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by MAOA, AANAT, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. phytanate-CoA ligase

  Catalysed by MAOA, AANATcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by MAOA, AANAT, SLC27A2, ACSL4 and 5 morecytosolOne of 15 routes

• prostaglandin E1Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by MAOA, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosol

• leukotriene A4Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, GLO1 and 1 moreextracellular space, cytosolOne of 2 routes

• S-formylglutathioneReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, ADH1C and 5 moreextracellular space, cytosol

• sphing-4-enineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by MAOA, AANAT, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by MAOA, AANAT, SAT1, SAT2cytosolOne of 3 routes

• L-methionineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by MAOA, AANAT, NAGScytosol, mitochondrial matrix

• N-sulfo-D-glucosamineReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by ALDH2, ALDH1B1, SLC4A1, SGSHmitochondrial matrix, extracellular space, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by ALDH2, ALDH1B1, SLC4A1, STSmitochondrial matrix, extracellular space, cytosolOne of 3 routes

• L-tryptophanReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by MAOA, DDC, TPH1, TPH2

• L-alanineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by MAOA, AANATcytosol, mitochondrial matrix

• leukotriene C4Reach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 6 routes

• L-asparagineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by MAOA, AANAT, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by MAOA, AANAT, NAGScytosol, mitochondrial matrix

• adenosine 5'-phosphosulfateReach from here →
  1. 5-Hydroxyindoleacetaldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. Transport of 5-Hydroxyindoleacetate
  3. ATP:sulfate adenylyltransferase

  Catalysed by ALDH2, ALDH1B1, SLC4A1, PAPSS1 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• glutathione disulfideReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by MAOA, SLCO1A2, SLCO1B3, GPX5 and 8 moreextracellular space, cytosolOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• an acyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by MAOA, AANAT, ASAH1, ACER2 and 2 morecytosol, Golgi apparatusOne of 2 routes

• histamineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by MAOA, AANAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by MAOA, AANAT, SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by MAOA, AANAT, SLC27A2, SLC27A5cytosolOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by MAOA, SLCO1A2, SLCO1B3, SQORextracellular space, cytosol, mitochondrial matrix

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by MAOA, DDC, TPH1, TPH2

• dopamineReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by MAOA, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes