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Proteins/UNIPROT:P30837
Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes. Shows an absolute preference for NAD(+) as no activity is detected with NADP(+). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro. Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency. In vitro, it can also display a nitroglycerin reductase activity. Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo..
Function from UniProtKB (P30837), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
108 statements
108 statements · 6 reference databases · Subject: ALDH1B1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
43 reactions
(5-hydroxyindol-3-yl)acetaldehyde+water+NAD(+)(5-hydroxyindol-3-yl)acetate+2proton+NADH(2-)
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR00051CC BY 4.0Reference data
5 names
Resolves to: ALDH1B1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR00088CC BY 4.0Reference data
MAM01981c+water+NAD(+)(R)-glycerate+2proton+NADH(2-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3cytosol
Human-GEM MAR00456CC BY 4.0Reference data
MAM01981m+water+NAD(+)(R)-glycerate+2proton+NADH(2-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3mitochondrial matrix
Human-GEM MAR00459CC BY 4.0Reference data
MAM00585c+2proton+NADH(2-)MAM00600c+water+NAD(+)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageReversibleBalancedEC 1.2.1.3cytosol
Human-GEM MAR01132CC BY 4.0Reference data
MAM00585m+2proton+NADH(2-)MAM00600m+water+NAD(+)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageReversibleBalancedEC 1.2.1.3mitochondrial matrix
Human-GEM MAR01133CC BY 4.0Reference data
MAM00585r+2proton+NADH(2-)MAM00600r+water+NAD(+)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageReversibleBalancedEC 1.2.1.3endoplasmic reticulum
Human-GEM MAR01134CC BY 4.0Reference data
MAM00601x+water+NAD(+)MAM00586x+2proton+NADH(2-)
Catalysed by ALDH3A2 or ALDH2 or ALDH1B1 or ALDH9A1 or ALDH7A1
Reaction pageLeft to rightBalancedEC 1.2.1.3peroxisome
Human-GEM MAR01289CC BY 4.0Reference data
MAM01685m+2water+NAD(+)MAM01681m+3proton+NADH(2-)
Catalysed by ALDH2 or ALDH1B1 or ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR01372CC BY 4.0Reference data
(R)-lactaldehyde+water+NAD(+)(R)-lactic acid+2proton+NADH(2-)
Catalysed by ALDH18A1 or ALDH2 or ALDH5A1 or ALDH6A1 or ALDH1B1 or ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.3mitochondrial matrix
Human-GEM MAR01474CC BY 4.0Reference data
water+4-acetamidobutanal+NAD(+)MAM00952m+2proton+NADH(2-)
Catalysed by ALDH2 or ALDH1B1 or ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR01523CC BY 4.0Reference data