cis-aconitic acid

Three steps

• L-leucineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dATP:D-glucosamine 6-phosphotransferase

  Catalysed by SLC25A1, PKM, PKLR, HK1 and 2 moremitochondrial matrix, cytosol

• keto-D-fructose 6-phosphateReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dATP:D-fructose 6-phosphotransferase

  Catalysed by SLC25A1, PKM, PKLR, HK1 and 3 moremitochondrial matrix, cytosol

• CHEBI:15971Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular space

• CHEBI:16174Reach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. ATP:dADP phosphotransferase

  Catalysed by SLC25A1, PKM, PKLR, NME4 and 4 moremitochondrial matrix, cytosolOne of 20 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosol

• (R)-carnitineReach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by ACOD1, SUGCT, SLC22A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• iodideReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC26A4mitochondrial matrix, cytosol, extracellular space

• ubiquinonesReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC25A1, FH, SDHD, SDHB and 2 moremitochondrial matrix, cytosol

• L-valineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• L-arginineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• (S)-lactateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by SLC25A1, ME2, ME3, LDHA and 4 moremitochondrial matrix, cytosol

• quinolinic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Transport of Quinolinic Acid

  Catalysed by SLC25A1, SLC25A10, SLC22A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• 2-oxobutanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by SLC25A1, ME2, ME3, KYAT1mitochondrial matrix, cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by SLC25A1, ME2, ME3, FAHD1mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:16857Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular space

• ferrocytochrome cReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by SLC25A1, SLC25A10, SUOXmitochondrial matrix, cytosol

• (R)-3-hydroxybutyric acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by SLC25A1, ME2, ME3, AGXTmitochondrial matrix, cytosol

• L-isoleucineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SLC25A1, SLC26A6, CLTRN, SLC6A20mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• aceneuramateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by SLC25A1, ME2, ME3, NPLmitochondrial matrix, cytosol

• 5'-deoxyadenosineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC25A1, ME2, ME3, TYW1B and 1 moremitochondrial matrix, cytosol

• 3-hydroxy-3-methylglutarateReach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by ACOD1, SUGCTmitochondrial matrix

• L-cysteineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• indole-3-pyruvateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Steryl-Sulfatase

  Catalysed by SLC25A1, SLC25A10, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• thymidineReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. pyruvate kinase (dTDP)
  3. dTTP + H2O = thymidine + triphosphate + H(+)

  Catalysed by SLC25A1, PKM, PKLR, SAMHD1mitochondrial matrix, cytosol

• glycine betaineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A12mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• urateReach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by ACOD1, SUGCT, SLC22A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methyl-2-oxopentanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• CHEBI:17895Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 3-phenylpyruvateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• CHEBI:18019Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular space

• thiocyanateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A1, SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC25A1, FH, FAHmitochondrial matrix, cytosol

• triphosphateReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. pyruvate kinase (dTDP)
  3. dTTP + H2O = thymidine + triphosphate + H(+)

  Catalysed by SLC25A1, PKM, PKLR, SAMHD1mitochondrial matrix, cytosol

• L-glutamineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC25A1, SLC26A6, SLC6A14mitochondrial matrix, cytosol, extracellular space

• dTDPReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A1, ME2, ME3, PKM and 1 moremitochondrial matrix, cytosolOne of 12 routes

• CHEBI:18095Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, CLTRN, SLC6A20mitochondrial matrix, cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC25A1, SLC26A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• hydrogen cyanideReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A1, SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by ACOD1, SUGCT, SLC22A24mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A1, AGXT2mitochondrial matrix, cytosolOne of 3 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SLC25A1, SLC26A6, SLC6A5mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• dUMPReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. thymidine kinase (deoxyuridine)

  Catalysed by SLC25A1, PKM, PKLRmitochondrial matrix, cytosolOne of 2 routes