formic acid

Two steps

• L-cysteineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosolOne of 2 routes

• glycine betaineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A12extracellular space, cytosolOne of 3 routes

• 4-methylumbelliferyl acetateReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A1, CES2 and 2 moreextracellular space, cytosol

• urateReach from here →
  1. transport of formate and L-lactate (cytosol to extracellular)
  2. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

• CHEBI:17895Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosolOne of 2 routes

• all-trans-retinalReach from here →
  1. transport of formate and retinoate (cytosol to extracellular)
  2. retinoate reduction

  Catalysed by SLC16A4, SLC16A5extracellular space, cytosol

• CHEBI:18019Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol

• 4-fumarylacetoacetateReach from here →
  1. transport of acetoacetate and formate (cytosol to extracellular)
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC16A4, SLC16A5, FAHextracellular space, cytosol

• L-glutamineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosol

• dTDPReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. pyruvate kinase (dTDP)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol

• CHEBI:18095Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC26A4, CLTRN, SLC6A20extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of 3-Ureidopropionate

  Catalysed by SLC26A4extracellular space, cytosolOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Formate:tetrahydrofolate ligase (ADP-forming)
  2. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by MTHFD1, GARTcytosol

• CHEBI:18381Reach from here →
  1. Formate:tetrahydrofolate ligase (ADP-forming)
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by MTHFD1, ATICcytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Formate:tetrahydrofolate ligase (ADP-forming)
  2. 10-formyltetrahydrofolate:NADP+ oxidoreductase

  Catalysed by MTHFD1, ALDH1L1, ALDH1L2cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SLC26A4, SLC6A5extracellular space, cytosolOne of 2 routes

• hypochlorous acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Peroxidase

  Catalysed by SLC26A4, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)

  Catalysed by SLC26A4, SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLC16A4, SLC16A5, SLC16A1, CYP17A1extracellular space, cytosol, endoplasmic reticulum

• malonic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Malonate Transport, Antiport with Chloride

  Catalysed by SLC26A4extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. L-Serine:pyruvate aminotransferase

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosolOne of 2 routes

• 3-oxopropanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• D-serineReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. D-serine = pyruvate + NH4(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• (R)-lactic acidReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. transport of acetoacetate and formate (cytosol to extracellular)
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by SLC16A4, SLC16A5, HMGCL, HMGCLL1extracellular space, cytosol

• 2-iminopropanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• phosphoenolpyruvic acidReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. pyruvate kinase (dTDP)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosol

• 13-cis-retinalReach from here →
  1. transport of formate and retinoate (cytosol to extracellular)
  2. retinal dehydrogenase (13-cis-retinal)

  Catalysed by SLC16A4, SLC16A5, ALDH1A2, ALDH1A1extracellular space, cytosol, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• N-(acetyl)-sphing-4-enineReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, ASAH1extracellular space, cytosol

• taurineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC26A4, SLC6A6extracellular space, cytosolOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• acetoacetyl-CoAReach from here →
  1. transport of acetoacetate and formate (cytosol to extracellular)
  2. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by SLC16A4, SLC16A5, AACSextracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes

• butanoyl-CoAReach from here →
  1. transport of butyrate and formate (cytosol to extracellular)
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC16A4, SLC16A5, ACSM4, ACSM1 and 4 moreextracellular space, cytosolOne of 2 routes

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. Formate:tetrahydrofolate ligase (ADP-forming)
  2. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)

  Catalysed by MTHFD1cytosolOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, AMDHD2extracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

• guanidinoacetateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of Guanidinoacetic Acid

  Catalysed by SLC26A4extracellular space, cytosol

• L-methionineReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 moreextracellular space, cytosolOne of 3 routes

• L-tryptophanReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosolOne of 2 routes

• beta-alanineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A6, SLC6A14extracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. transport of formate and pyruvate (cytosol to extracellular)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 20 routes

• L-asparagineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Asparagine by Atb0 Transporter

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosolOne of 2 routes

• L-phenylalanineReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter

  Catalysed by SLC26A4, SLC6A14extracellular space, cytosolOne of 2 routes

• N-acetylputrescineReach from here →
  1. transport of acetate and formate (cytosol to extracellular)
  2. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, HDAC10extracellular space, cytosol