glycolate

Three steps

• octanamideReach from here →
  1. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  2. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by GRHPR, PAM

• (9Z,12Z,15Z)-octadecatrienamideReach from here →
  1. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  2. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by GRHPR, PAM

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by GRHPR, AGXT, AGXT2, GARTcytosol, mitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by GRHPR, AGXT, AGXT2, DPEP1 and 1 morecytosol, mitochondrial matrix

• glycyldehydrophenylalanineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by GRHPR, AGXT, AGXT2, DPEP1cytosol, mitochondrial matrix

• an N-(fatty acyl)-glycineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by GRHPR, AGXT, AGXT2, GLYATL2cytosol, mitochondrial matrix

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by GRHPR, AGXT, AGXT2, GLYATL2cytosol, mitochondrial matrix

• (7Z)-octadecenoyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by GRHPR, CLYBL, CPT1A, CPT1C and 1 morecytosol, mitochondrial matrixOne of 3 routes

• CHEBI:15345Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by GRHPR, CLYBL, AACScytosol, mitochondrial matrixOne of 2 routes

• cholineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by GRHPR, CLYBL, CHATcytosol, mitochondrial matrix, nucleus

• acetylpyruvateReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by GRHPR, AGXT, AGXT2, FAHD1cytosol, mitochondrial matrix

• all-trans-retinoic acidReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC16A4 and 5 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• CHEBI:15380Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by GRHPR, CLYBL, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GRHPR, CLYBL, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Production of Tiglylcarnitine

  Catalysed by GRHPR, CLYBL, CPT1A, CPT1Bcytosol, mitochondrial matrixOne of 2 routes

• isobutyryl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by GRHPR, CLYBL, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by GRHPR, CLYBL, GLYATcytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by GRHPR, CLYBL, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by GRHPR, CLYBL, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 11 routes

• CHEBI:15519Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. propanoyl-CoA C-acyltransferase

  Catalysed by GRHPR, CLYBL, ACAA1, SCP2 and 1 morecytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by GRHPR, CLYBL, SLC27A2, ACSL4 and 6 morecytosol, mitochondrial matrixOne of 11 routes

• oleoyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by GRHPR, CLYBL, CPT1A, CPT1C and 1 morecytosol, mitochondrial matrixOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Phenylacetate:CoA ligase

  Catalysed by GRHPR, CLYBLcytosol, mitochondrial matrixOne of 3 routes

• propionyl-CoAReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by GRHPR, CLYBL, ACSS3, ACSS2 and 1 morecytosol, mitochondrial matrixOne of 44 routes

• CHEBI:15570Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC3A2 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• L-leucineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 7 routes

• CHEBI:15611Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GRHPR, AGXT, AGXT2, GNMTcytosol, mitochondrial matrix

• CHEBI:15650Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by GRHPR, CLYBL, ZDHHC11B, NAA10 and 30 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15699Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• CHEBI:15727Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by GRHPR, CLYBL, NAA10cytosol, mitochondrial matrix

• formateReach from here →
  1. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  2. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by GRHPR, HAO1, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15746Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by GRHPR, CLYBL, SAT1, SAT2cytosol, mitochondrial matrixOne of 2 routes

• malonateReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by GRHPR, CLYBL, SLC25A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15971Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• homogentisateReach from here →
  1. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by GRHPR, AADAT, HPDcytosolOne of 2 routes

• sulfateReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. Glyoxylate:oxygen oxidoreductase
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by GRHPR, HAO1, SLC26A6cytosol, peroxisome, extracellular spaceOne of 7 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by GRHPR, AGXT, AGXT2cytosol, mitochondrial matrix

• 11-cis-retinolReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by GRHPR, CLYBL, DGAT1, LRAT and 3 morecytosol, mitochondrial matrix

• L-citrullineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC7A9 and 2 morecytosol, mitochondrial matrix, extracellular space

• L-valineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• oxaloacetateReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by GRHPR, AGXT, AGXT2, PCcytosol, mitochondrial matrixOne of 10 routes

• L-arginineReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• CHEBI:16523Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC3A2 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. PROTEIN_BS

  Catalysed by GRHPR, AGXT, AGXT2cytosol, mitochondrial matrix

• (S)-lactateReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by GRHPR, AGXT, AGXT2, LDHA and 4 morecytosol, mitochondrial matrix

• 2-oxoglutaramateReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by GRHPR, AGXT, AGXT2, KYAT1cytosol, mitochondrial matrixOne of 3 routes

• enol-phenylpyruvateReach from here →
  1. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by GRHPR, AADAT, MIF

• 3-fumarylpyruvateReach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by GRHPR, AGXT, AGXT2, FAHD1cytosol, mitochondrial matrix

• CHEBI:16856Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by GRHPR, AGXT, AGXT2, GSScytosol, mitochondrial matrix

• CHEBI:16857Reach from here →
  1. glycolate:NADP+ oxidoreductase
  2. L-Alanine:glyoxylate aminotransferase
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by GRHPR, AGXT, AGXT2, SLC3A2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 4 routes