glycocholate

Two steps

• cholateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes

• hydrogen sulfideReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by ABCC4, TSTD1inner side of the membrane, outer side of the membrane

• adipic acidReach from here →
  1. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  2. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by SLC22A24, SUGCTinner side of the membrane, outer side of the membrane

• an alcoholReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by ABCC4, CP, PRDX6inner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• serotoninReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• chenodeoxycholateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• glycochenodeoxycholateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. solute carrier organic anion transporter (GSH)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 7 routes

• glycolithocholic acidReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• tert-butanolReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by ABCC4, CLIC2, GPX1, GPX2 and 2 moreinner side of the membrane, outer side of the membrane

• gamma-Glu-AlaReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO1A2, SLCO1B3, GGT1, GGT5 and 4 moreextracellular space, cytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glutaryl-CoAReach from here →
  1. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  2. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by SLC22A24, SUGCTinner side of the membrane, outer side of the membraneOne of 4 routes

• prostaglandin E1Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 6 routes

• prostaglandin H2Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO1A2, SLCO1B3, GLO1, GLOD4extracellular space, cytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1A2, SLCO1B3, ADH1C, ADH1A and 4 moreextracellular space, cytosolOne of 2 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• leukotriene C4Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. leukotriene C4 synthase (GSH)

  Catalysed by SLCO1A2, SLCO1B3, LTC4Sextracellular space, cytosolOne of 7 routes

• glutathione disulfideReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 35 routes

• taurolithocholate 3-sulfateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 5-oxo-L-prolineReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by ABCC4, CHAC2, CHAC1inner side of the membrane, outer side of the membrane

• histamineReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• kynurenateReach from here →
  1. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by SLC22A24, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, SQORextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• dopamineReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin E2Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glutathione gamma-glutamylaminopeptidase

  Catalysed by SLCO1A2, SLCO1B3, GGTLC3, GGT1 and 4 moreextracellular space, cytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by ABCC4, SQORinner side of the membrane, outer side of the membrane

• (R)-noradrenalineReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• ursodeoxycholateReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• prostaglandin G2Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosolOne of 4 routes

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  2. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX2, GPX4inner side of the membrane, outer side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, PTGES, MGST3, GPX1 and 3 moreinner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• thromboxane B2Reach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• an S-substituted glutathioneReach from here →
  1. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by ABCC4, GSTT4, GSTA4, GSTZ1 and 20 moreinner side of the membrane, outer side of the membraneOne of 2 routes