CHEBI:16856

Three steps

• 5-aminolevulinateReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by LTC4S, ALAS1, ALAS2cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and isoleucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A5, BCAT1cytosol, extracellular spaceOne of 2 routes

• chenodeoxycholateReach from here →
  1. leukotriene C4 synthase (GSH)
  2. transport of leukotriene C4 (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by LTC4S, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A5, GOT2, GOT1, TATcytosol, extracellular spaceOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycochenodeoxycholic acidReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by LTC4S, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by LTC4S, AADATcytosolOne of 11 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by LTC4S, GCATcytosol, mitochondrial matrix

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A6, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-iminopropanoateReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by CTH, RIDAcytosol

• phosphoenolpyruvic acidReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. pyruvate kinase (dTDP)

  Catalysed by CTH, PKM, PKLRcytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by CTH, NPLcytosol

• tert-butanolReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• N-(acetyl)-sphing-4-enineReach from here →
  1. transport of acetylcholine and GSH (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHE and 1 moreextracellular space, cytosol

• 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
  1. alcohol dehydrogenase (formaldehyde)
  2. S-formylglutathione + H2O = formate + glutathione + H(+)
  3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

  Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 4 morecytosolOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by LTC4S, GLDC, GCSHcytosol, mitochondrial matrix

• taurineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 30 moreextracellular space, cytosolOne of 4 routes

• 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moreextracellular space, cytosol

• a 3-acylpyruvateReach from here →
  1. cystine to cysteine conversion
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by CTH, FAHD1cytosol

• (R)-methylmalonyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 30 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 29 moreextracellular space, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 30 moreextracellular space, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 29 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 31 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 37 moreextracellular space, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 35 moreextracellular space, cytosolOne of 11 routes

• dodecanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 37 moreextracellular space, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. glutarate + succinyl-CoA = glutaryl-CoA + succinate

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24, SUGCTextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• eicosanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 37 moreextracellular space, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 32 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 37 moreextracellular space, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 37 moreextracellular space, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 30 moreextracellular space, cytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. phytanate-CoA ligase

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 29 moreextracellular space, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLCO1B1, ZDHHC11B, NAA10, ESCO2 and 36 moreextracellular space, cytosolOne of 15 routes

• 13,14-dihydro-15-oxo-prostaglandin E2Reach from here →
  1. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)
  3. 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + NADPH + H(+)

  Catalysed by SLCO1A2, SLCO1B3, HPGD, PTGR1 and 2 moreextracellular space, cytosolOne of 2 routes

• D-alanineReach from here →
  1. glutathione gamma-glutamylaminopeptidase
  2. gamma-glutamyltransferase (alanine)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by LTC4S, PIPOXcytosolOne of 3 routes

• 7,8-dihydrofolateReach from here →
  1. transport of GSH and thyroxine (cytosol to extracellular)
  2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO3 and 1 moreextracellular space, cytosolOne of 4 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 hydrolysis
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by LTC4S, SHMT1, SHMT2cytosol

• 5-formimidoyltetrahydrofolateReach from here →
  1. Formation of Homocystine
  2. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
  3. 5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase

  Catalysed by MTR, FTCDcytosol

• leukotriene E4Reach from here →
  1. leukotriene C4 synthase (GSH)
  2. leukotriene C4 + H2O = leukotriene D4 + L-glutamate
  3. leukotriene D4 + H2O = leukotriene E4 + glycine

  Catalysed by LTC4S, GGT1, GGT5, DPEP1 and 1 morecytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. cystine to cysteine conversion
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC7A6, ASLcytosol, extracellular spaceOne of 4 routes

• carnosineReach from here →
  1. transport of GSH and histamine (cytosol to extracellular)
  2. L-histidine + H(+) = histamine + CO2
  3. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)

  Catalysed by SLCO1A2, SLCO1B3, HDC, CARNS1extracellular space, cytosol

• 4-guanidinobutanoateReach from here →
  1. cystine to cysteine conversion
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by SLC7A6, GATMcytosol, extracellular space

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. transport of acetylcholine and GSH (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLCO1A2, SLCO1B3, BCHE, ACHE and 1 moreextracellular space, cytosol

• O-acetyl-(R)-carnitineReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. Utilized Transport
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1Bextracellular space, cytosol, endoplasmic reticulumOne of 9 routes

• 3-guanidinopropanoateReach from here →
  1. cystine to cysteine conversion
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by SLC7A6, GATMcytosol, extracellular space

• ethanolamineReach from here →
  1. transport of arachidonate and GSH (cytosol to extracellular)
  2. fatty acylamide amidohydrolase
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by FAAH, FAAH2extracellular space, cytosol

• D-ornithineReach from here →
  1. cystine to cysteine conversion
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes