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Proteins/UNIPROT:Q6GMR7
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates..
Function from UniProtKB (Q6GMR7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
11 statements
11 statements · 4 reference databases · Subject: FAAH2 · Sources: Hetionet, Human-GEM, Reactome, Rhea
6 reactions
2-phenylacetamide+waterproton+ammonium+MAM02720c
Catalysed by FAAH2
Reaction pageLeft to rightBalancedEC 3.5.1.4cytosol
Human-GEM MAR07756CC BY 4.0Reference data
indole-3-acetamide+waterproton+(indol-3-yl)acetate+ammonium
Catalysed by FAAH2
4 names
Resolves to: FAAH2
Human-GEM MAR09534CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine+waterethanolamine+(5Z,8Z,11Z,14Z)-eicosatetraenoate
Reaction pageLeft to rightBalanced
Rhea RHEA:26136CC BY 4.0Reference data
(9Z)-octadecenamide+water(9Z)-octadecenoate+ammonium
Reaction pageLeft to rightBalanced
Rhea RHEA:26506CC BY 4.0Reference data
N-(9Z-octadecenoyl) ethanolamine+waterethanolamine+(9Z)-octadecenoate
Reaction pageLeft to rightBalanced
Rhea RHEA:45060CC BY 4.0Reference data
N-hexadecanoylethanolamine+waterethanolamine+hexadecanoate
Catalysed by FAAH or NAAA or FAAH2
Reaction pageLeft to rightBalanced
Rhea RHEA:45064CC BY 4.0Reference data