2-oxoglutaramate

Three steps

• L-kynurenineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. Transport of L-Kynurenine

  Catalysed by KYAT1, GOT2, TAT, SLC7A8mitochondrial matrix, extracellular space, cytosolOne of 5 routes

• beta-alanineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by KYAT1, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• leukotriene C4Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. leukotriene C4 hydrolysis

  Catalysed by KYAT1, SLC7A5extracellular space, cytosol

• taurocyamineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by KYAT1, SLC7A6, GATMextracellular space, cytosol

• L-glutamate 5-semialdehydeReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

  Catalysed by KYAT1, SLC7A6, OATextracellular space, cytosol

• N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)

  Catalysed by KYAT1, SLC7A13, AGAinner side of the membrane, outer side of the membrane

• 3-hydroxy-L-kynurenineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by KYAT1, KYNUcytosol

• L,L-cystathionineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by KYAT1, NAGScytosol, mitochondrial matrix

• gamma-L-glutamyl-L-cysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 2 moreextracellular space, cytosolOne of 2 routes

• 6-amino-2-oxohexanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and lysine (cytosol to extracellular)
  3. L-lysine:oxygen 2-oxidoreductase (deaminating)

  Catalysed by KYAT1, SLC7A6extracellular space, cytosol, peroxisome

• L-homocysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by KYAT1, SLC7A5, BHMT2extracellular space, cytosol

• S-methyl-L-methionineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by KYAT1, SLC7A5, BHMT2extracellular space, cytosol

• L-tyrosineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylalanine Transaminase, Mitochondrial
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by KYAT1, GOT2, TAT, PAHmitochondrial matrixOne of 4 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by KYAT1, AGXT2cytosolOne of 7 routes

• an acyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by KYAT1, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatusOne of 3 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by KYAT1, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• histamineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and histidine (cytosol to extracellular)
  3. L-histidine carboxy-lyase (histamine-forming)

  Catalysed by KYAT1, SLC7A6, HDCextracellular space, cytosol

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by KYAT1, SLC7A13, PAICSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 5-guanidino-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by KYAT1, SLC7A6, IL4I1extracellular space, cytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by KYAT1, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by KYAT1, SLC7A5, IDO1, TDO2 and 1 moreextracellular space, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by KYAT1, SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• L-methionine (S)-S-oxideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by KYAT1, SLC7A5, MSRAextracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by KYAT1, SLC7A5, MSRB3, MSRB1 and 1 moreextracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine

  Catalysed by KYAT1, AADAT, AGXT2One of 3 routes

• deoxycholoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by KYAT1, SLC27A2, SLC27A5cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by KYAT1, SLC7A5, GLYATL2extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosolOne of 4 routes

• 4-aminobutanoateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Transport of L-Glutamine by Atb0 Transporter
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by KYAT1, SLC6A14, SLC6A12extracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by KYAT1, SLC7A5, TPOextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by KYAT1, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by KYAT1, SLC7A5extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by KYAT1, SLC3A2, SLC7A5, SLC7A10 and 1 moreextracellular space, cytosolOne of 6 routes

• decanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by KYAT1, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by KYAT1, CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

• L-cysteinylglycineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by KYAT1, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by KYAT1, AADAT, HOGA1

• 3-hydroxyisovaleryl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by KYAT1, CPT1A, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by KYAT1, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosol

• xanthurenateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by KYAT1, AADAT, KYAT3

• Mo-molybdopterinReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. L-Glutamine:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by KYAT1, MOCOScytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by KYAT1, CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by KYAT1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by KYAT1, AADAT, HOGA1