N(2)-acetyl-L-ornithine

Three steps

• 2-phenylethylamineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by ACY1, SLC7A6, DDCcytosol, extracellular space

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by ACY1, SLC7A6, PFAScytosol, extracellular space

• ophthalmateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by ACY1, GATM, GSScytosol

• S-methylmercury-L-cysteineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by ACY1, SLC7A6, SLC7A8cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by ACY1, SLC7A6, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• biocytinReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by ACY1, SLC25A2, SLC25A15, BTDcytosol, inner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 7 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by ACY1, GATM, AGXT2cytosolOne of 2 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by ACY1, GATM, SHMT1cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by ACY1, SLC7A6, CARS2cytosol, extracellular space

• CHEBI:240943Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ACY1, GATM, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrix

• phenylacetylglycineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by ACY1, GATM, GLYATcytosolOne of 3 routes

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450

  Catalysed by ACY1, CYP17A1, CYP21A2cytosol, endoplasmic reticulum

• 5-hydroxytryptophanReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by ACY1, SLC7A6, TPH1, TPH2cytosol, extracellular spaceOne of 2 routes

• 11-deoxycortisolReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by ACY1, CYP17A1, CYP21A2cytosol, endoplasmic reticulumOne of 3 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by ACY1, ASAH1, PLA2G15cytosolOne of 3 routes

• CHEBI:28666Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. LTD4 hydrolysis

  Catalysed by ACY1, GATMcytosol

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by ACY1, CYP17A1cytosol, endoplasmic reticulumOne of 6 routes

• pyridoxine 5'-phosphateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by ACY1, SLC7A6, SCLYcytosol, extracellular space

• N-acetyl-L-cysteineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ACY1, SLC7A6, NAGScytosol, extracellular space, mitochondrial matrix

• K(+)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by ACY1, SLC7A6, SLC1A1cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, CARS1cytosol, extracellular space

• Phe-tRNA(Phe)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, FARSB, FARSAcytosol, extracellular space

• Gly-tRNA(Gly)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by ACY1, GATM, GARS1cytosol

• Trp-tRNA(Trp)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, WARS1cytosol, extracellular space

• Ile-tRNA(Ile)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, IARS1cytosol, extracellular space

• Gln-tRNA(Gln)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, QARS1cytosol, extracellular space

• isocyanateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by ACY1, SLC7A9, LACC1cytosol, extracellular space

• Asn-tRNA(Asn)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of asparagine and ornithine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by ACY1, SLC7A6, NARS1cytosol, extracellular space

• chlorine(.)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular spaceOne of 33 routes

• glycocholateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ACY1, GATM, BAATcytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by ACY1, SLC7A6, CTHcytosol, extracellular spaceOne of 2 routes

• L-aspartateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by ACY1, SLC7A6, AGXT2cytosol, extracellular spaceOne of 19 routes

• CHEBI:30249Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by ACY1, SLC7A6, IDO1, TDO2 and 1 morecytosol, extracellular space

• 3-hydroxypyruvic acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

• 3-oxopropanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by ACY1, SLC7A6, IL4I1cytosol, extracellular space

• di-mu-sulfido-diiron(2+)Reach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by ACY1, SLC7A6, NDUFAB1, FDXR and 5 morecytosol, extracellular space, mitochondrial matrix

• a phenolReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. a phenyl acetate + H2O = a phenol + acetate + H(+)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by ACY1, PON1, PON2, PON3cytosol

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by ACY1, SLC7A6, BCAT2, BCAT1cytosol, extracellular space

• D-cysteineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of alanine and ornithine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by ACY1, SLC7A6, SLC7A10cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by ACY1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 11 routes

• 5-aminolevulinateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ACY1, GATM, ALAS1, ALAS2cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of isoleucine and ornithine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by ACY1, SLC7A6, BCAT1cytosol, extracellular spaceOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by ACY1, SLC7A6, GOT2, GOT1 and 1 morecytosol, extracellular spaceOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by ACY1, GATM, BAATcytosol

• glycochenodeoxycholic acidReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ACY1, GATM, BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. N2-Acetyl-L-ornithine amidohydrolase
  2. L-Arginine:glycine amidinotransferase
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by ACY1, GATM, AADATcytosolOne of 12 routes