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PathwaysReactions grouped under one name
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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Compound

17alpha,21-dihydroxypregnenolone

CHEBI:27832ChEBI

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What it touches on the way

Inferred

Not reported; assembled from reference reactions.

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

CYP11B2ProteinUNIPROT:P19099metabolized byInferred only24 paths24 endpoints
CYP11B1ProteinUNIPROT:P15538metabolized byInferred only21 paths21 endpoints
HSD3B1ProteinUNIPROT:P14060substrate ofInferred only18 paths18 endpoints
HSD3B2ProteinUNIPROT:P26439substrate ofInferred only18 paths18 endpoints

What the reference databases state

Chemical structure

17alpha,21-dihydroxypregnenolone has the functional parent pregnenoloneCompoundChEBI CHEBI:27832Inferred only

Statements

6 statements

6 statements · 1 reference database · Subject: 17alpha,21-dihydroxypregnenolone · Sources: Human-GEM

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17alpha,21-dihydroxypregnenolone is converted to 11-deoxycortisolCompoundHuman-GEM MAR01949Inferred only
17alpha-hydroxypregnenolone is converted to 17alpha,21-dihydroxypregnenoloneCompoundHuman-GEM MAR01948Inferred only
17alpha,21-dihydroxypregnenolone is metabolised by CYP11B1ProteinHuman-GEM MAR01950Inferred only
17alpha,21-dihydroxypregnenolone is metabolised by CYP11B2ProteinHuman-GEM MAR01950Inferred only
17alpha,21-dihydroxypregnenolone is a substrate of HSD3B1ProteinHuman-GEM MAR01949Inferred only
17alpha,21-dihydroxypregnenolone is a substrate of HSD3B2ProteinHuman-GEM MAR01949Inferred only

Reactions

3 reactions

17alpha-hydroxypregnenolone+proton+NADPH(4-)+dioxygen17alpha,21-dihydroxypregnenolone+water+NADP(3-)
Catalysed by CYP21A2
Reaction pageLeft to rightBalancedEC 1.14.14.16GO:0005829
Human-GEM MAR01948CC BY 4.0Reference data
17alpha,21-dihydroxypregnenolone+NAD(+)11-deoxycortisol+proton+NADH(2-)
Catalysed by HSD3B1 or HSD3B2
Reaction pageLeft to rightBalancedEC 1.1.1.145, 5.3.3.1GO:0005829
Human-GEM MAR01949CC BY 4.0Reference data
17alpha,21-dihydroxypregnenolone+2proton+dioxygen+2MAM02828cMAM00283c+water+2MAM02665c
Catalysed by CYP11B1 or CYP11B2
Reaction pageLeft to rightBalance undeterminableEC 1.14.15.4GO:0005829
Human-GEM MAR01950CC BY 4.0Reference data

Other names

2 names

Resolves to: 17alpha,21-dihydroxypregnenolone

Systematic name: 3beta,17,21-trihydroxypregn-5-en-20-one3β,17,21-trihydroxypregn-5-en-20-one