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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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17alpha,21-dihydroxypregnenolone

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

6 compounds within 3 steps: 1 in 1, 1 in 2, 4 in 3

Does it reach a compound?

One step

11-deoxycortisolReach from here →
1. 11-Deoxycortisol delta5-delat4-isomerase
Catalysed by HSD3B1, HSD3B2cytosol

Two steps

cortisolReach from here →
1. 11-Deoxycortisol delta5-delat4-isomerase
2. steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Catalysed by HSD3B1, HSD3B2, CYP11B1, CYP11B2cytosol, mitochondrial matrixOne of 2 routes

Three steps

acetaldehydeReach from here →
Catalysed by HSD3B1, HSD3B2, CYP11B1, CYP11B2 and 1 morecytosol, mitochondrial matrix, endoplasmic reticulum
cortisoneReach from here →

Catalysed by HSD3B1, HSD3B2, CYP11B1, CYP11B2 and 1 more

cytosol, mitochondrial matrix

One of 5 routes

11beta-hydroxyandrost-4-ene-3,17-dioneReach from here →

11-Deoxycortisol delta5-delat4-isomerase
steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
steroid 11beta-monooxygenase (cortisol)

Catalysed by HSD3B1, HSD3B2, CYP11B1, CYP11B2 and 2 morecytosol, mitochondrial matrixOne of 4 routes

acetateReach from here →

11-Deoxycortisol delta5-delat4-isomerase
steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
steroid 11beta-monooxygenase (cortisol)

Catalysed by HSD3B1, HSD3B2, CYP11B1, CYP11B2 and 2 morecytosol, mitochondrial matrixOne of 3 routes