methanethiol

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

150 compounds within 3 steps: 3 in 1, 14 in 2, 133 in 3

Three steps

(3S)-citramalateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. hydrogen sulfide + 2 O2 = sulfate + H(+)
3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)
Catalysed by SELENBP1, SOD1, SLC25A14, SLC25A30inner side of the membrane, outer side of the membraneOne of 2 routes
di-mu-sulfido-diiron(2+)Reach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. De novo synthesis of 2Fe2S
Catalysed by SELENBP1, CBS, NDUFAB1, FDXR and 5 morecytosol, mitochondrial matrix
an organic disulfideReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
3. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
Catalysed by SELENBP1, SUMF1
glycochenodeoxycholateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by SELENBP1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane
taurocholateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by SELENBP1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane
tert-butanolReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O
Catalysed by SELENBP1, TSTD1, CLIC2, GPX1 and 3 more
L-ornithineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. transport of cysteine and ornithine (cytosol to extracellular)
Catalysed by SELENBP1, CBS, SLC7A6cytosol, extracellular spaceOne of 2 routes
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
3. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
Catalysed by SELENBP1, ALDH9A1, ADI1One of 2 routes
a thioesterReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
3. a thioester + H2O = a thiol + a carboxylate + H(+)
Catalysed by SELENBP1, SUMF1, PNKD
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
Catalysed by SELENBP1, SQOR, NQO2
glycineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by SELENBP1, PIPOXOne of 6 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SELENBP1, TSTD1, GPX1, GPX2 and 1 more
7,8-dihydrofolateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. formaldehyde to 5,10-methylene-THF conversion
3. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Catalysed by SELENBP1, TYMScytosol
(6R)-5,10-methenyltetrahydrofolateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. formaldehyde to 5,10-methylene-THF conversion
3. 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
Catalysed by SELENBP1, MTHFD2, MTHFD2Lcytosol, mitochondrial matrixOne of 4 routes
(R)-S-lactoylglutathioneReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. (R)-S-lactoylglutathione = methylglyoxal + glutathione
Catalysed by SELENBP1, TSTD1, GLO1
L-methionineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. transport of cysteine and methionine (cytosol to extracellular)
Catalysed by SELENBP1, CBS, SLC7A5cytosol, extracellular spaceOne of 6 routes
N-sulfo-D-glucosamineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. hydrogen sulfide + 2 O2 = sulfate + H(+)
3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
Catalysed by SELENBP1, SOD1, SGSH
dehydroepiandrosterone 3-sulfateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. hydrogen sulfide + 2 O2 = sulfate + H(+)
3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
Catalysed by SELENBP1, SOD1, STS
L-tryptophanReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. transport of cysteine and tryptophan (cytosol to extracellular)
Catalysed by SELENBP1, CBS, SLC7A5cytosol, extracellular spaceOne of 4 routes
L-alanineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. transport of alanine and cysteine (cytosol to extracellular)
Catalysed by SELENBP1, CBS, SLC7A5cytosol, extracellular spaceOne of 14 routes
leukotriene C4Reach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. leukotriene C4 = leukotriene A4 + glutathione
Catalysed by SELENBP1, TSTD1, MGST3, GSTM4 and 2 more
L-asparagineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. transport of asparagine and cysteine (cytosol to extracellular)
Catalysed by SELENBP1, CBS, SLC7A5cytosol, extracellular spaceOne of 4 routes
L-phenylalanineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. transport of cysteine and phenylalanine (cytosol to extracellular)
Catalysed by SELENBP1, CBS, SLC7A5cytosol, extracellular spaceOne of 6 routes
gamma-L-glutamyl-L-cysteineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)
Catalysed by SELENBP1, CBS, GCLC, GCLMcytosolOne of 2 routes
adenosine 5'-phosphosulfateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. hydrogen sulfide + 2 O2 = sulfate + H(+)
3. ATP:sulfate adenylyltransferase
Catalysed by SELENBP1, SOD1, PAPSS1, PAPSS2cytosolOne of 4 routes
N,N-dimethylglycineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
3. (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]
Catalysed by SELENBP1, PIPOX, DMGDH
glutathione disulfideReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by SELENBP1, TSTD1One of 23 routes
trans-4-hydroxy-L-prolineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
Catalysed by SELENBP1, SQOR, PRODH2
5-oxo-L-prolineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. glutathione = L-cysteinylglycine + 5-oxo-L-proline
Catalysed by SELENBP1, TSTD1, CHAC2, CHAC1
kynurenateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
Catalysed by SELENBP1, MPST, AADAT
S-sulfanyl-L-cysteineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine
Catalysed by SELENBP1, CBS, CARS2cytosol
N-formyl-L-kynurenineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
3. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
Catalysed by SELENBP1, ALDH9A1, AFMID
N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. (R)-4'-phosphopantothenate:L-cysteine ligase
Catalysed by SELENBP1, CBS, PPCScytosolOne of 4 routes
L-prolineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
Catalysed by SELENBP1, SQOR, PRODH, PRODH2
estrone 3-sulfateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. hydrogen sulfide + 2 O2 = sulfate + H(+)
3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)
Catalysed by SELENBP1, SOD1, STS
3-sulfino-L-alanineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. L-Cysteine:oxygen oxidoreductase
Catalysed by SELENBP1, CBS, CDO1cytosolOne of 2 routes
L-cysteinylglycineReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. glutathione + H2O = L-cysteinylglycine + L-glutamate
Catalysed by SELENBP1, TSTD1, GGT3P, GGT1 and 3 moreOne of 2 routes
(5-hydroxyindol-3-yl)acetateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. hydrogen sulfide + 2 O2 = sulfate + H(+)
3. Transport of 5-Hydroxyindoleacetate
Catalysed by SELENBP1, SOD1, SLC4A1extracellular space, cytosolOne of 2 routes
dTMPReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. formaldehyde to 5,10-methylene-THF conversion
3. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Catalysed by SELENBP1, TYMScytosol
3-demethylubiquinol-10Reach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)
Catalysed by SELENBP1, SQOR, COQ3
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by SELENBP1, TSTD1, GPX1, GPX4
thio-Mo-molybdopterinReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by SELENBP1, CBS, MOCOScytosol
glycodeoxycholateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by SELENBP1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SELENBP1, TSTD1, GPX1, GPX2 and 1 more
a methyl thioetherReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
3. a thiol + S-adenosyl-L-methionine = a methyl thioether + S-adenosyl-L-homocysteine + H(+)
Catalysed by SELENBP1, SUMF1, TMT1B, TMT1A
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SELENBP1, TSTD1, PTGES, MGST3 and 4 more
(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SELENBP1, TSTD1, GPX1, GPX4
an S-substituted glutathioneReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by SELENBP1, TSTD1, GSTT4, GSTA4 and 21 moreOne of 2 routes
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Catalysed by SELENBP1, TSTD1, GPX1, GSTA1 and 2 more
taurochenodeoxycholateReach from here →
1. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by SELENBP1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane