malonate

Three steps

• CHEBI:18019Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• thiocyanateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A10, MPST, TSTinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• 4-fumarylacetoacetateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC25A10, FH, FAHinner side of the membrane, outer side of the membrane, cytosol

• L-glutamineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• dTDPReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A10, ME2, ME3, PKM and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• CHEBI:18095Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• hydrogen cyanideReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and sulfite (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SLC25A10, MPST, TSTinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A10, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• hypochlorous acidReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 2 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• K(+)Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC1A7 and 4 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• Asp-tRNA(Asp)Reach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, DARS1inner side of the membrane, outer side of the membrane, cytosol

• glycolateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by SLC25A10, CLYBL, GRHPRinner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SLC25A10inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• acetateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• propionic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 5 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• butyric acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A10, ME2, ME3, SLC16A4 and 5 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by SLC25A10, ME2, ME3, AGXTinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• (indol-3-yl)acetateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SLC25A10, SDHB, SDHA, DHODHinner side of the membrane, outer side of the membrane

• glutarateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STS and 2 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC25A10, GOT2inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• pentanoateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  3. pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, STS and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

• N-carbamoyl-L-aspartateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, CADinner side of the membrane, outer side of the membrane

• 3-oxopropanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC25A10, ME2, ME3, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrix

• a phenolReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, ARSL and 5 moreinner side of the membrane, outer side of the membrane

• D-serineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by SLC25A10, ME2, ME3, SRRinner side of the membrane, outer side of the membrane, mitochondrial matrix

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SLC25A10, CLYBL, AADATinner side of the membrane, outer side of the membrane

• (R)-lactic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC25A10, ME2, ME3, LDHDinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• (S)-lactic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC25A10, ME2, ME3, LDHB and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 5 routes

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 2-iminopropanoateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by SLC25A10, ME2, ME3, RIDAinner side of the membrane, outer side of the membrane, mitochondrial matrix

• phosphoenolpyruvic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. Citrate Transport, Mitochondrial
  3. transport of citrate and PEP (cytosol to mitochondria)

  Catalysed by SLC25A10, SLC25A1inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 9 routes

• N-acetyl-beta-neuraminic acidReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC25A10, ME2, ME3, NPLinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC4A1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• taurineReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC26A6 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SLC25A10, SDHB, SDHA, NQO2inner side of the membrane, outer side of the membrane

• a 3-acylpyruvateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SLC25A10, ME2, ME3, FAHD1inner side of the membrane, outer side of the membrane, mitochondrial matrix

• glycineReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC25A10, CLYBL, AADATinner side of the membrane, outer side of the membraneOne of 18 routes

• prostaglandin F2alphaReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC25A35 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 7,8-dihydrofolateReach from here →
  1. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
  2. Folate Transport by Oats
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SLC25A14, SLC25A30, SLC25A10, SLC22A8 and 3 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC25A10, FH, ASLinner side of the membrane, outer side of the membrane, cytosolOne of 4 routes