CHEBI:15765

Three steps

• cholateReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by DDC, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• hydrogen sulfideReach from here →
  1. solute carrier (L-dopa)
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC3A2, SLC7A5, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:30249Reach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC3A2, SLC7A5, IDO1, TDO2 and 1 moreextracellular space, cytosol

• formic acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A5, SLC6A14, SLC26A4extracellular space, cytosolOne of 2 routes

• anthranilic acidReach from here →
  1. solute carrier (L-dopa)
  2. Transport of L-Kynurenine
  3. L-Kynurenine hydrolase

  Catalysed by SLC3A2, SLC7A5, SLC43A1, KYNUextracellular space, cytosol

• malonic acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by SLC3A2, SLC7A5, SLC6A14extracellular space, cytosolOne of 2 routes

• (9Z)-octadecenoateReach from here →
  1. solute carrier (L-dopa)
  2. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by SLC3A2, SLC7A5, PM20D1extracellular space, cytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• D-lysineReach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. solute carrier (L-dopa)
  2. transport of arginine and leucine (cytosol to extracellular)
  3. Putrescine Export via Putrescine/Arginine Antiporter

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC7A7extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC3A2, SLC7A5, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. solute carrier (L-dopa)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by SLC3A2, SLC7A5, SLC7A13, CADextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and methionine (cytosol to extracellular)
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC3A2, SLC7A5, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. De novo synthesis of 2Fe2S

  Catalysed by SLC3A2, SLC7A5, SLC7A9, SLC3A1 and 7 moreextracellular space, cytosol, mitochondrial matrix

• serotoninReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. solute carrier (L-dopa)
  2. transport of isoleucine and leucine (cytosol to extracellular)
  3. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC3A2, SLC7A5, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. solute carrier (L-dopa)
  2. transport of alanine and leucine (cytosol to extracellular)
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC3A2, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. solute carrier (L-dopa)
  2. transport of alanine and leucine (cytosol to extracellular)
  3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC3A2, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC3A2, SLC7A5, ALAS1, ALAS2extracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of isoleucine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC3A2, SLC7A5, BCAT1extracellular space, cytosolOne of 2 routes

• chenodeoxycholateReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (chenodiol)

  Catalysed by DDC, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and tyrosine (cytosol to extracellular)
  3. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC3A2, SLC7A5, GOT2, GOT1 and 1 moreextracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC3A2, SLC7A5, BAATextracellular space, cytosol

• taurocholateReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by DDC, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• glycochenodeoxycholic acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC3A2, SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. solute carrier (L-dopa)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by SLC3A2, SLC7A5, BCAT2, AADATextracellular space, cytosol, mitochondrial matrixOne of 12 routes

• 3-hydroxyisovaleric acidReach from here →
  1. solute carrier (L-dopa)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. 4-methyl-2-oxopentanoate decarboxylation

  Catalysed by SLC3A2, SLC7A5, BCAT2, ALOX12B and 1 moreextracellular space, cytosol, mitochondrial matrix

• glycolithocholic acidReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 6 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC3A2, SLC7A5, GCATextracellular space, cytosol, mitochondrial matrix

• gamma-Glu-AlaReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by DDC, SLCO1A2, SLCO1B3, GGT1 and 5 morecytosol, extracellular spaceOne of 2 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC3A2, SLC7A5, GLDC, GCSHextracellular space, cytosol, mitochondrial matrix

• taurineReach from here →
  1. solute carrier (L-dopa)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC3A2, SLC7A5, SLC6A14, SLC6A6extracellular space, cytosolOne of 4 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• (R)-methylmalonyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SLC3A2, SLC7A5, ALDH6A1extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SLC3A2, SLC7A5extracellular space, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SLC3A2, SLC7A5, ACP2extracellular space, cytosol, mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SLC3A2, SLC7A5extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SLC3A2, SLC7A5, ACAA1, MYO5Bextracellular space, cytosol, mitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 7 routes

• butanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, ACSM4, ACSM1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 9 routes

• glutaryl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Production of Glutaryl Carnitine

  Catalysed by SLC3A2, SLC7A5, CPT1A, CPT1C and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 12 routes

• itaconyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SLC3A2, SLC7A5, SUCLG1, SUCLG2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 11 routes

• octanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by SLC3A2, SLC7A5, CROTextracellular space, cytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. phytanate-CoA ligase

  Catalysed by SLC3A2, SLC7A5extracellular space, cytosol, mitochondrial matrixOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 15 routes

• prostaglandin E1Reach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 4 routes