propionyl-CoA

Three steps

• a 1,3-diacylglycerolReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 3 morecytosol, Golgi apparatus

• a 1,2-diacylglycerolReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 6 morecytosol, Golgi apparatusOne of 2 routes

• gamma-Glu-AlaReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ACOT7, GGT1, GGT5, GGTLC2 and 3 morecytosol, mitochondrial matrix, extracellular space

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 2 morecytosol, mitochondrial matrix

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. Active Transport
  2. Utilized Transport
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by FAAHmitochondrial matrix, cytosol, endoplasmic reticulum

• an N-acylsphing-4-enineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 7 morecytosol, Golgi apparatus

• N-tetracosanoylsphinganineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 8 morecytosol

• N-hexacosanoylsphinganineReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 8 morecytosol

• O-propanoyl-(R)-carnitineReach from here →
  1. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
  2. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2
  3. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA

  Catalysed by PCCA, PCCB, ECHDC1, CRATmitochondrial matrix

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. Active Transport
  2. Utilized Transport
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by DGAT1, LIPA, PNPLA4, LIPE and 1 moremitochondrial matrix, cytosol, endoplasmic reticulum

• 16-hydroxyhexadecanoateReach from here →
  1. Active Transport
  2. Utilized Transport
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by CYP4F2, CYP4F3mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 4 morecytosol, Golgi apparatus

• a 3-acylpyruvateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• acetoacetyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetoacetate and propanoate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

• succinyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
  3. (R)-methylmalonyl-CoA = succinyl-CoA

  Catalysed by ACOT7, ALDH6A1, MMUTcytosol, mitochondrial matrixOne of 3 routes

• (2E)-butenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

  Catalysed by ACOT7, ACSM4, ACSM1, ACSM2A and 5 morecytosol, mitochondrial matrixOne of 4 routes

• 2-methyl-3-oxobutanoyl-CoAReach from here →
  1. propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
  2. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2
  3. propanoyl-CoA + acetyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA

  Catalysed by PCCA, PCCB, ECHDC1, ACAT1mitochondrial matrix

• 3-methyl-(2E)-glutaconyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine-N-acyltransferase (3-methylcrotonoylglycine)
  3. 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)

  Catalysed by ACOT7, GLYAT, MCCC1, MCCC2cytosol, mitochondrial matrixOne of 2 routes

• 3-oxohexadecanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 7 morecytosol

• (2E)-glutaconyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Production of Glutaryl Carnitine
  3. glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2

  Catalysed by ACOT7, CPT1A, CPT1C, CPT1B and 1 morecytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
  3. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• hexadecanoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase
  3. (2E)-hexadecenoyl-CoA + NADPH + H(+) = hexadecanoyl-CoA + NADP(+)

  Catalysed by ACOT7, CPT1A, CPT1C, CPT1B and 1 morecytosolOne of 3 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. Propanoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• prostaglandin H2Reach from here →
  1. Active Transport
  2. Utilized Transport
  3. prostaglandin-endoperoxide synthase (arachidonate)

  Catalysed by PTGS1, PTGS2mitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• D-alanineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by ACOT7, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• S-adenosyl 3-(methylsulfanyl)propylamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

  Catalysed by ACOT7, SAT1, SAT2, SRMcytosol

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Active Transport
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by ALOX5, ALOX15, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulum

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Active Transport
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by ALOX15B, ALOX15, ALOX12mitochondrial matrix, cytosol, endoplasmic reticulum

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Active Transport
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by ALOX5mitochondrial matrix, cytosol, endoplasmic reticulum

• 7,8-dihydrofolateReach from here →
  1. Propanoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by ACOT7, BAAT, MTO1cytosol

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 2 morecytosol, mitochondrial matrix

• leukotriene A4Reach from here →
  1. Active Transport
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O

  Catalysed by ALOX5mitochondrial matrix, cytosol, endoplasmic reticulum

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. Active Transport
  2. Utilized Transport
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by ALOX15B, ALOX15mitochondrial matrix, cytosol, endoplasmic reticulum

• propane-1,3-diamineReach from here →
  1. Propanoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine

  Catalysed by ACOT7, SAT1, SAT2, DHPScytosol

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular space

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. Palmitate:CoA ligase (AMP-forming)
  3. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by ACOT7, SLC27A2, ACSL4, ACSL3 and 9 morecytosol

• a 1-acylglycerone 3-phosphateReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatusOne of 2 routes

• an N-acylglycineReach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 4 morecytosol, Golgi apparatusOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by ACOT7, NAGS, GOT2, GOT1cytosol, mitochondrial matrixOne of 4 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. Propanoyl-CoA hydrolase
  2. transport of propanoate and pyruvate (cytosol to extracellular)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by ACOT7, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• guanidinoacetateReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• D-threonineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by ACOT7, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. Propanoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACOT7, ASAH1, ACER2, ACER1 and 3 morecytosol, Golgi apparatus

• L-tryptophanReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 22 routes

• glutathioneReach from here →
  1. Propanoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by ACOT7, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrix

• L-threonineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by ACOT7, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-kynurenineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by ACOT7, KYNUcytosol, mitochondrial matrix

• beta-alanineReach from here →
  1. Propanoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by ACOT7, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 5 routes