an N-acylsphing-4-enine

1. UDP-alpha-D-galactose:N-acylsphingosine D-galactosyltransferase

Catalysed by UGT8cytosolOne of 5 routes

1. an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Catalysed by FADS3

1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

Catalysed by GBA1, GBA2One of 3 routes

1. ceramide:phosphatidylcholine cholinephosphotransferase

Catalysed by SGMS1, SGMS2Golgi apparatusOne of 8 routes

1. ceramide:phosphatidylcholine cholinephosphotransferase

Catalysed by SGMS1, SGMS2Golgi apparatusOne of 6 routes

1. UDP-glucose:N-acylsphingosine D-glucosyltransferase

Catalysed by UGCGcytosolOne of 2 routes

1. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

Catalysed by UGT8One of 2 routes

1. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

Catalysed by GBA1, GBA3One of 2 routes

1. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

Catalysed by UGCGOne of 2 routes

1. an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid

Catalysed by NAAA, ASAH1, ACER2, ACER1 and 2 more

1. N-Acylsphingosine amidohydrolase

Catalysed by ASAH1lysosome

1. an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

Catalysed by AGK, CERK

1. acyl-CoA:sphingosine N-acyltransferase

Catalysed by ASAH1, ACER2, ACER1, ASAH2Golgi apparatusOne of 4 routes

1. acyl-CoA:sphingosine N-acyltransferase

Catalysed by ASAH1, ACER2, ACER1, ASAH2Golgi apparatusOne of 2 routes

1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

Catalysed by SGMS1, SGMS2, SAMD8

1. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

Catalysed by SGMS2

1. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine

Catalysed by SGMS1, SGMS2

1. acyl-CoA:sphingosine N-acyltransferase
2. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 4 moreGolgi apparatus, mitochondrial matrixOne of 17 routes

1. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

Catalysed by GBA1, GBA2, CH25H