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Proteins/UNIPROT:P41247
Has abundant triacylglycerol lipase activity. Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides. Additionally possesses acylglycerol transacylase and phospholipase A2 activities. Able to catalyze fatty acyl CoA-dependent retinol esterification during epidermal maturation, when pH becomes acidic..
Function from UniProtKB (P41247), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
44 statements
44 statements · 6 reference databases · Subject: PNPLA4 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
27 reactions
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+MAM01807e
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3extracellular space
5 names
Resolves to: PNPLA4
Human-GEM MAR00003CC BY 4.0Reference data
water+a triacylglycerola 1,2-diacyl-sn-glycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00665CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00667CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00668CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00669CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00670CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00671CC BY 4.0Reference data
a 1,2-diacyl-sn-glycerol+watera monoacylglycerol+proton+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or DAGLB or LIPC or CEL or PNLIP or PNPLA2 or LIPF and 3 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.3cytosol
Human-GEM MAR00672CC BY 4.0Reference data
water+an all-trans-retinyl esterproton+all-trans-retinol+fatty acid
Catalysed by PNPLA4 or LIPE or PNPLA3 or LIPG or AADAC or DAGLA or RBP4 or CES5A or DAGLB or LIPC or CEL or CES3 and 8 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 3.1.1.1, 3.1.1.3cytosol
Human-GEM MAR06636CC BY 4.0Reference data
all-trans-retinol+an acyl-CoAan all-trans-retinyl ester+coenzyme A(4-)
Catalysed by DGAT1 or PNPLA4 or AWAT2 or DGAT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:11488CC BY 4.0Reference data
a triacylglycerol+watera diacylglycerol+a fatty acid+hydron
Catalysed by DDHD2 or LPL or LIPF or ABHD2 or LIPC or PNLIP or CEL or AADAC or PNPLA4 or PNLIPRP2 or LIPE or PNLIPRP3 and 7 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12044CC BY 4.0Reference data
all-trans-retinyl hexadecanoate+waterall-trans-retinol+hexadecanoate+hydron
Catalysed by PNLIP or PNPLA4 or LIPE
Reaction pageLeft to rightBalanced
Rhea RHEA:13933CC BY 4.0Reference data