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Proteins/UNIPROT:P38571
Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions..
Function from UniProtKB (P38571), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
415 statements
415 statements · 7 reference databases · Subject: LIPA · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
133 reactions
MAM01498l+waterCHEBI:1307929+proton+dodecanoate
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03538CC BY 4.0Reference data
MAM01510l+waterCHEBI:1307929+proton+MAM03051l
8 names
Resolves to: LIPA
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03539CC BY 4.0Reference data
MAM01501l+waterCHEBI:1307929+proton+tetradecanoate
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03540CC BY 4.0Reference data
MAM01487l+waterMAM00128l+CHEBI:1307929+proton
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03541CC BY 4.0Reference data
MAM01479l+waterMAM00117l+CHEBI:1307929+proton
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03542CC BY 4.0Reference data
MAM01470l+waterCHEBI:1307929+proton+MAM02745l
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03543CC BY 4.0Reference data
MAM01506l+waterCHEBI:1307929+proton+MAM02690l
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03544CC BY 4.0Reference data
cholesteryl hexadecanoate+waterCHEBI:1307929+proton+hexadecanoic acid
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03545CC BY 4.0Reference data
MAM01477l+waterMAM01197l+CHEBI:1307929+proton
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03546CC BY 4.0Reference data
MAM01505l+waterCHEBI:1307929+proton+(9Z)-hexadecenoate
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03547CC BY 4.0Reference data
MAM01495l+waterCHEBI:1307929+proton+MAM02456l
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03548CC BY 4.0Reference data
MAM01454l+waterMAM00003l+CHEBI:1307929+proton
Reaction pageLeft to rightBalancedEC 3.1.1.13lysosome
Human-GEM MAR03549CC BY 4.0Reference data