kinetensin

Three steps

• nitric oxideReach from here →
  1. Chymase
  2. transport of arginine and leucine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by CMA1, SLC3A2, SLC7A6, SLC7A7 and 3 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by CMA1, SLC7A5, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. Chymase
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by CMA1, SLC7A6, ACY1extracellular space, cytosol

• anthranilateReach from here →
  1. Chymase
  2. Transport of L-Kynurenine
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by CMA1, SLC43A1, KYNUextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by CMA1, SLC7A5, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. Chymase
  2. transport of leucine and methionine (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by CMA1, SLC3A2, SLC7A5, MARS1extracellular space, cytosol

• (S)-lactateReach from here →
  1. Chymase
  2. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by CMA1, CNDP2extracellular space

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. Chymase
  2. transport of leucine and methionine (cytosol to extracellular)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by CMA1, SLC3A2, SLC7A5, AADATextracellular space, cytosol

• 2-oxobutanoateReach from here →
  1. Chymase
  2. transport of leucine and threonine (cytosol to extracellular)
  3. L-threonine ammonia-lyase (2-oxobutanoate-forming)

  Catalysed by CMA1, SLC7A5, SDS, SDSLextracellular space, cytosol

• tryptamineReach from here →
  1. Chymase
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by CMA1, SLC7A5, DDCextracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. Chymase
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by CMA1, SLC7A5, KYAT1extracellular space, cytosolOne of 4 routes

• enol-phenylpyruvateReach from here →
  1. Chymase
  2. Phenylalanine Transaminase, Mitochondrial
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by CMA1, GOT2, TAT, MIFextracellular space, mitochondrial matrix

• CHEBI:16856Reach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by CMA1, SLC7A5, GSSextracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by CMA1, SLC7A5, DAOextracellular space, cytosol, peroxisome

• N-acetyl-L-aspartateReach from here →
  1. Chymase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by CMA1, SLC7A13, NAT8Lextracellular space, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. Chymase
  2. transport of chloride and leucine (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by CMA1, SLC6A14, SLC26A6extracellular space, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. Chymase
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by CMA1, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• anilineReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by CMA1, NAT2, NAT1extracellular space, mitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by CMA1extracellular space, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. Chymase
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by CMA1, SLC7A5extracellular space, cytosolOne of 3 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. Chymase
  2. transport of leucine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by CMA1, SLC7A5, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. Chymase
  2. transport of arginine and leucine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by CMA1, SLC3A2, SLC7A6, SLC7A7extracellular space, cytosol, mitochondrial matrix

• AH2Reach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CMA1, SLC7A5, MOCOSextracellular space, cytosolOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by CMA1, SLC7A5, ALAS1, ALAS2 and 1 moreextracellular space, cytosol, mitochondrial matrix

• indole-3-pyruvateReach from here →
  1. Chymase
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by CMA1, SLC7A5, IL4I1extracellular space, cytosolOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by CMA1, HADHA, ACADVL, HADHBextracellular space, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by CMA1, SLC7A5, AARS1extracellular space, cytosol

• glycine betaineReach from here →
  1. Chymase
  2. transport of chloride and leucine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by CMA1, SLC6A14, SLC6A12extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. Chymase
  2. transport of histidine and leucine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by CMA1, SLC7A6, HALextracellular space, cytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. Chymase
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by CMA1, SLC7A5, TPH1, TPH2extracellular space, cytosol

• CHEBI:17927Reach from here →
  1. Chymase
  2. transport of arginine and leucine (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by CMA1, SLC3A2, SLC7A6, SLC7A7extracellular space, cytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by CMA1, SLC7A5, SLC1A4extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. Chymase
  2. transport of chloride and leucine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by CMA1, SLC6A14extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by CMA1, SLC7A5, GARTextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. Chymase
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by CMA1, SLC7A5, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by CMA1, SLC7A5, GSSextracellular space, cytosol

• 2-aminoisobutanoateReach from here →
  1. Chymase
  2. transport of alanine and leucine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by CMA1, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• biocytinReach from here →
  1. Chymase
  2. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by CMA1, SLC7A7, BTDextracellular space, inner side of the membrane, outer side of the membrane

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by CMA1, SLC7A5, AGXT2extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by CMA1, SLC7A5, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. Chymase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by CMA1, SLC7A9, SLC3A1, CARS2extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by CMA1, HADHA, ACAA2, HADHBextracellular space, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by CMA1, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, mitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by CMA1, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, mitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by CMA1, HADHA, ACADVL, HADHBextracellular space, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by CMA1, HADHA, ACADVL, HADHBextracellular space, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by CMA1, ECHS1, ACAA2, HADHextracellular space, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Chymase
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by CMA1, ECHS1, ACAA2, HADHextracellular space, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. Chymase
  2. transport of glycine and leucine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by CMA1, SLC7A5, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. Chymase
  2. transport of chloride and leucine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by CMA1, SLC6A14, LPOextracellular space, cytosolOne of 4 routes