a quinone

Three steps

• L-isoleucineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of isoleucine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:17208Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. glutathione:dehydroascorbate oxidoreductase

  Catalysed by SQOR, ETHE1mitochondrial matrix, cytosol

• homocysteineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. Formation of Homocystine

  Catalysed by SQOR, ETHE1mitochondrial matrix, cytosol

• D-glyceraldehydeReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  3. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)

  Catalysed by GPD2, TPI1, TKFCOne of 2 routes

• an aldehydeReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + a carboxylate(in) = orotate(in) + a carboxylate(out)
  3. an aldehyde + O2 + H2O = a carboxylate + H2O2 + H(+)

  Catalysed by DHODH, SLC22A13, AOX1inner side of the membrane, outer side of the membrane

• L-cysteineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 4 routes

• inosineReach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. inosine:phosphate alpha-D-ribosyltransferase

  Catalysed by NQO2, PNPcytosol

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Steryl-Sulfatase

  Catalysed by SDHB, SLC25A10, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• urateReach from here →
  1. (S)-dihydroorotate + a quinone = orotate + a quinol
  2. orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)
  3. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by DHODH, SLC22A12, SLC22A13inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17797Reach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. D-Ribose 1,5-phosphomutase

  Catalysed by NQO2, PNP, PGM2cytosol

• methylarsonous acidReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GSTO1, GSTO2

• CHEBI:17895Reach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of proline and tyrosine (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 3 routes

• ubiquinolReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. succinate:quinone oxidoreductase
  3. thioredoxin-disulfide reductase (NADPH) (ubiquinone)

  Catalysed by SDHB, SDHD, SDHA, SDHC and 2 moremitochondrial matrix, cytosolOne of 6 routes

• CHEBI:18019Reach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of lysine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 2 routes

• thiocyanateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SDHB, SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. transport of glutamine and proline (cytosol to extracellular)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 1 morecytosol, extracellular spaceOne of 4 routes

• CHEBI:18095Reach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. prolyl 4-hydroxylase (AKG)

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• xanthosineReach from here →
  1. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol
  2. purine nucleoside phosphorylase (nicotinamide)
  3. xanthosine:orthophosphate ribosyltransferase

  Catalysed by NQO2, PNPcytosol

• arsenic triglutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by SQOR, ETHE1, AS3MTOne of 3 routes

• hydrogen cyanideReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by SDHB, SLC25A10, MPST, TSTmitochondrial matrix, cytosolOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by SQOR, ETHE1, MGST3

• Xaa-L-Pro dipeptideReach from here →
  1. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
  2. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

  Catalysed by CYC1, UQCRFS1, PRODH, PRODH2 and 1 moreouter side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GPX4

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GPX4

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GPX4

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX1, GPX4

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, GPX4

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. (R)-malate + a quinone = enol-oxaloacetate + a quinol
  2. oxaloacetate = enol-oxaloacetate
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SDHB, SDHA, FAHD2B, FAHD1 and 2 more

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by SQOR, ETHE1, GSTP1

• folic acidReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Folate Transport by Oats

  Catalysed by SDHB, SLC25A10, SLC22A8, SLC22A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• hydroxyacetoneReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. dihydroxyacetone phosphate = methylglyoxal + phosphate
  3. aldose reductase (methylglyoxal)

  Catalysed by GPD2, TPI1, AKR7A2, AKR1A1 and 1 morecytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SQOR, ETHE1, GPX5, GPX1 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• beta-D-fructoseReach from here →
  1. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  2. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  3. beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)

  Catalysed by GPD2, ALDOB, KHK

• CHEBI:28666Reach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by SQOR, ETHE1, SLCO2A1mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• a dicarboxylateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A35, SLC25A34mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-ascorbic acidReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by SQOR, ETHE1, CLIC1, GSTO1 and 1 more

• chlorine(.)Reach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2 and 2 morecytosol, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• cholateReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. Persulfide dioxygenase
  3. solute carrier organic anion transporter (cholate)

  Catalysed by SQOR, ETHE1, SLCO1A2, SLCO1B3mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• hydrogen sulfideReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SDHB, SLC25A10mitochondrial matrix, cytosolOne of 3 routes

• D-aspartateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
  2. L-Proline:NADP+ 5-oxidoreductase
  3. Aspartate Intake by System Asct-1 Transporter

  Catalysed by PRODH, PRODH2, PYCR3, PYCR2cytosol, extracellular spaceOne of 10 routes

• oxalateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A14, SLC26A2 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. Citrate Transport, Mitochondrial

  Catalysed by SDHB, FH, SLC25A1cytosol, mitochondrial matrixOne of 7 routes

• maleateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. transport of malonate and sulfite (cytosol to mitochondria)

  Catalysed by SDHB, SLC25A10mitochondrial matrix, cytosolOne of 4 routes

• an alcoholReach from here →
  1. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by SQOR, ETHE1, CP, PRDX6

• isocitric acidReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SDHB, FH, SLC25A1cytosol, mitochondrial matrixOne of 3 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. (R)-malate + a quinone = enol-oxaloacetate + a quinol
  2. oxaloacetate = enol-oxaloacetate
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SDHB, SDHA, FAHD2B, FAHD1 and 2 moremitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. a quinone + succinate = fumarate + a quinol
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SDHB, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes