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Proteins/UNIPROT:P09467
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain..
Function from UniProtKB (P09467), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
138 statements
138 statements · 6 reference databases · Subject: FBP1 · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
2 reactions
MAM01841c+waterketo-D-fructose 6-phosphate+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.3.11cytosol
Human-GEM MAR04377CC BY 4.0Reference data
beta-D-fructose 1,6-bisphosphate+waterbeta-D-fructose 6-phosphate+hydrogenphosphate
4 names
Resolves to: FBP1
Rhea RHEA:11064CC BY 4.0Reference data