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Proteins/UNIPROT:P17858
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity)..
Function from UniProtKB (P17858), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
278 statements
278 statements · 6 reference databases · Subject: PFKL · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
keto-D-fructose 6-phosphate+UTPMAM01841c+proton+UDP
Catalysed by PFKP or PFKL or PFKM
Reaction pageLeft to rightBalancedEC 2.7.1.11cytosol
Human-GEM MAR04301CC BY 4.0Reference data
ATP+keto-D-fructose 6-phosphateADP+MAM01841c+proton
Catalysed by
6 names
Resolves to: PFKL
Reaction pageLeft to rightBalancedEC 2.7.1.11cytosol
Human-GEM MAR04379CC BY 4.0Reference data
ATP+D-sedoheptulose 7-phosphateADP+proton+MAM02883c
Reaction pageLeft to rightBalancedEC 2.7.1.11cytosol
Human-GEM MAR04567CC BY 4.0Reference data
beta-D-fructose 6-phosphate+ATP(4-)beta-D-fructose 1,6-bisphosphate+ADP(3-)+hydron
Catalysed by PFKM or PFKL or PFKP
Reaction pageLeft to rightBalanced
Rhea RHEA:16109CC BY 4.0Reference data