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Proteins/UNIPROT:Q15311
Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L..
Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance..
Function from UniProtKB (Q15311), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
120 statements
120 statements · 6 reference databases · Subject: RALBP1 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, WikiPathways
4 reactions
MAM01139c+ATP+waterMAM01139e+ADP+proton+phosphate(3-)
Transported by RALBP1 or ABCC1
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR12013CC BY 4.0Reference data
8 names
Resolves to: RALBP1
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR12029CC BY 4.0Reference data
an S-substituted glutathione+ATP(4-)+wateran S-substituted glutathione+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC3 or ABCC4 or ABCC6 or ABCC1 or RALBP1 or ABCC10 or ABCC2 or ABCC11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:19121CC BY 4.0Reference data
leukotriene C4+ATP(4-)+waterleukotriene C4+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC3 or ABCC4 or ABCC6 or ABCC1 or RALBP1 or ABCC10 or ABCC2 or ABCC11
Reaction pageLeft to rightBalanced
Rhea RHEA:38963CC BY 4.0Reference data