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Proteins/UNIPROT:P67812
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids..
Function from UniProtKB (P67812), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
56 statements
56 statements · 3 reference databases · Subject: SEC11A · Sources: Hetionet, Reactome, WikiPathways
2 reactions
MAM00211c+waterprotein polypeptide chain+proton+N(6),N(6),N(6)-trimethyl-L-lysine
Catalysed by SPCS3 & SEC11A & SPCS2 & SEC11C & SPCS1
Reaction pageLeft to rightBalance undeterminableEC 3.4.21.89, 3.4.-.-cytosol
Human-GEM MAR06978CC BY 4.0Reference data
MAM00211r+waterprotein polypeptide chain+
8 names
Resolves to: SEC11A
Reaction pageLeft to rightBalance undeterminableEC 3.4.21.89, 3.4.-.-endoplasmic reticulum
Human-GEM MAR08029CC BY 4.0Reference data