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Proteins/UNIPROT:Q96NR8
Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids..
Function from UniProtKB (Q96NR8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
5 rows
23 statements
23 statements · 5 reference databases · Subject: RDH12 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
14 reactions
3 names
Resolves to: RDH12
Human-GEM MAR01098CC BY 4.0Reference data
9-cis-retinol+NADP(3-)9-cis-retinal+proton+NADPH(4-)
Catalysed by RDH11 or RDH8 or RDH12 or RDH13 or SDR16C5 or RDH14
Reaction pageLeft to rightBalancedEC 1.1.1.105cytosol
Human-GEM MAR01690CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
NADP(3-)+all-trans-retinolproton+NADPH(4-)+all-trans-retinal
Catalysed by RDH11 or DHRS9 or RDH8 or RDH10 or RDH12 or DHRS3
Reaction pageLeft to rightBalancedEC 1.1.1.300cytosol
Human-GEM MAR06630CC BY 4.0Reference data
NADP(3-)+all-trans-retinolproton+NADPH(4-)+all-trans-retinal
Catalysed by RDH11 or DHRS9 or RDH8 or RDH10 or RDH12 or DHRS3
Reaction pageLeft to rightBalancedEC 1.1.1.300endoplasmic reticulum
Human-GEM MAR06632CC BY 4.0Reference data
MAM01029c+proton+NADPH(4-)MAM01229c+NADP(3-)
Catalysed by HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or RDH13 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or HSD11B2 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06670CC BY 4.0Reference data
MAM00799m+NADP(3-)proton+NADPH(4-)+MAM03168m
Catalysed by DHRS2 or HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR42E2 or SDR42E1 or WWOX and 7 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-mitochondrial matrix
Human-GEM MAR09804CC BY 4.0Reference data
all-trans-retinol+NADP(3-)all-trans-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or DHRS3 or AKR1B1 or RDH10 or RDH13 or RDH11 or RDH12 or RDH14 or RDH8 or DHRS7
Reaction pageRight to leftBalanced
Rhea RHEA:25033CC BY 4.0Reference data
11-cis-retinol+NADP(3-)11-cis-retinal+NADPH(4-)+hydron
Catalysed by RDH11 or RDH12 or RDH14
Reaction pageDirection not assertedBalanced
Rhea RHEA:54912CC BY 4.0Reference data
9-cis-retinol+NADP(3-)9-cis-retinal+NADPH(4-)+hydron
Catalysed by AKR1B15 or AKR1B10 or AKR1B1 or AKR1C3 or RDH11 or RDH12 or RDH14
Reaction pageRight to leftBalanced
Rhea RHEA:54916CC BY 4.0Reference data
CHEBI:142603+NADP(3-)CHEBI:142591+NADPH(4-)+hydron
Catalysed by RDH12
Reaction pageDirection not assertedBalanced
Rhea RHEA:58328CC BY 4.0Reference data
CHEBI:142604+NADP(3-)CHEBI:142592+NADPH(4-)+hydron
Catalysed by RDH12
Reaction pageDirection not assertedBalanced
Rhea RHEA:58332CC BY 4.0Reference data