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Proteins/UNIPROT:Q7Z5P4
Plays a pivotal role in hepatic lipid metabolism. In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4..
[Isoform 2]: Has retinol/retinal dehydrogenase activity in vitro..
[Isoform 1]: Does not have retinol/retinal dehydrogenase activity in vitro..
Function from UniProtKB (Q7Z5P4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 5 reference databases · Subject: HSD17B13 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea
3 reactions
all-trans-retinol+NAD(1-)all-trans-retinal+NADH(2-)+hydron
Catalysed by DHRS7C or HSD17B6 or RDH16 or ADH1B or ADH4 or ADH7 or HSD17B13 or DHRS9
Reaction pageLeft to rightBalanced
Rhea RHEA:21284CC BY 4.0Reference data
6 names
Resolves to: HSD17B13
Catalysed by HSD17B6 or HSD17B1 or AKR1C4 or HSD17B2 or AKR1C3 or AKR1C2 or AKR1C1 or HSD17B12 or HSD17B13 or HSD17B11 or HSD17B8 or HSD17B10
Reaction pageReversibleBalanced
Rhea RHEA:24612CC BY 4.0Reference data
all-trans-retinal+NAD(1-)+waterall-trans-retinoate+NADH(2-)+2hydron
Catalysed by ALDH1A2 or ALDH1A1 or ALDH1B1 or ALDH1A3 or HSD17B13
Reaction pageLeft to rightBalanced
Rhea RHEA:42080CC BY 4.0Reference data