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Proteins/UNIPROT:Q9NXA8
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX..
Function from UniProtKB (Q9NXA8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
83 statements
83 statements · 7 reference databases · Subject: SIRT5 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
2water+MAM02866cL-glutamate(1-)+glycine+MAM02867c
Catalysed by SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or SIRT3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05336CC BY 4.0Reference data
3 names
Resolves to: SIRT5
water+MAM02548cacetate+MAM02867c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or MACROD1 or NAAA or SIRT3 or NTAN1 or MACROD2 or SIRT7
Reaction pageReversibleBalancedEC 3.5.1.-cytosol
Human-GEM MAR05339CC BY 4.0Reference data
water+MAM02867cammonium+MAM02865c
Catalysed by SIRT2 or SIRT6 or SIRT1 or SIRT5 or OARD1 or ACY3 or NTAQ1 or NTAN1 or SIRT7
Reaction pageLeft to rightBalancedEC 3.5.1.-cytosol
Human-GEM MAR05340CC BY 4.0Reference data
N(6)-glutaryl-L-lysyl-[protein]+NAD(1-)+water2''-O-glutaryl-ADP-D-ribose+nicotinamide+L-lysyl-[protein]
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47664CC BY 4.0Reference data
N(6)-succinyl-L-lysyl-[protein]+NAD(1-)+water2''-O-succinyl-ADP-D-ribose+nicotinamide+L-lysyl-[protein]
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47668CC BY 4.0Reference data
N(6)-malonyl-L-lysyl-[protein]+NAD(1-)+water2''-O-malonyl-ADP-D-ribose+nicotinamide+L-lysyl-[protein]
Catalysed by SIRT5
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:47672CC BY 4.0Reference data