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Proteins/UNIPROT:Q6UWP2
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones..
Function from UniProtKB (Q6UWP2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 5 reference databases · Subject: DHRS11 · Sources: Bgee, Hetionet, Human Protein Atlas, Rhea, WikiPathways
6 reactions
5 names
Resolves to: DHRS11
Rhea RHEA:24616CC BY 4.0Reference data
CHEBI:36836+NADP(3-)CHEBI:47788+NADPH(4-)+hydron
Catalysed by HSD3B1 or HSD17B7 or AKR1C1 or DHRS11
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:34787CC BY 4.0Reference data
androst-4-ene-3,11,17-trione+NADPH(4-)+hydronCHEBI:34133+NADP(3-)
Catalysed by HSD17B3 or AKR1C3 or AKR1D1 or DHRS11
Reaction pageLeft to rightBalanced
Rhea RHEA:53484CC BY 4.0Reference data
CHEBI:35343+NADP(3-)CHEBI:19168+NADPH(4-)+hydron
Catalysed by HSD17B3 or AKR1C3 or AKR1C1 or DHRS11
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:69284CC BY 4.0Reference data
CHEBI:34463+NADPH(4-)+hydronCHEBI:234448+NADP(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:85531CC BY 4.0Reference data
CHEBI:34134+NADPH(4-)+hydronCHEBI:234449+NADP(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:85543CC BY 4.0Reference data