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Proteins/UNIPROT:Q12905
Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71..
(Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3..
Function from UniProtKB (Q12905), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
167 statements
167 statements · 3 reference databases · Subject: ILF2 · Sources: gene ontology, Hetionet, Reactome
3 names
Resolves to: ILF2