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Proteins/UNIPROT:Q9NZC7
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm..
Function from UniProtKB (Q9NZC7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
147 statements
147 statements · 4 reference databases · Subject: WWOX · Sources: gene ontology, Hetionet, Human-GEM, Reactome
5 reactions
5 names
Resolves to: WWOX
Human-GEM MAR01098CC BY 4.0Reference data
MAM00747r+proton+NADPH(4-)MAM01087r+NADP(3-)
Catalysed by HSD17B14 or HSD3B7 or DHRS2 or HTATIP2 or RDH10 or MDH1B or RDH12 or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 and 12 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-endoplasmic reticulum
Human-GEM MAR01813CC BY 4.0Reference data
MAM01029c+proton+NADPH(4-)MAM01229c+NADP(3-)
Catalysed by HTATIP2 or MDH1B or RDH12 or CBR4 or CTBP1 or RDH13 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or HSD11B2 or SDR42E2 and 10 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06670CC BY 4.0Reference data
4-methyl-2-oxopentanoate+proton+NADH(2-)2-hydroxy-4-methylvaleric acid+NAD(+)
Catalysed by DHRS2 or HTATIP2 or MDH1B or CBR4 or CTBP1 or BDH2 or HSD11B1L or SDR9C7 or SDR16C5 or SDR42E2 or SDR42E1 or WWOX and 6 more alternatives
Reaction pageReversibleBalancedEC 1.1.1.-cytosol
Human-GEM MAR06925CC BY 4.0Reference data