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Proteins/UNIPROT:P22061
Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity)..
Function from UniProtKB (P22061), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
385 statements
385 statements · 3 reference databases · Subject: PCMT1 · Sources: Bgee, Hetionet, Reactome · Rows fetched: 300
2 reactions
MAM00203c+proton+CHEBI:16680MAM00202c+S-adenosyl-L-methionine
Catalysed by PCMT1
Reaction pageReversibleBalance undeterminableEC 2.1.1.77cytosol
Human-GEM MAR09500CC BY 4.0Reference data
[protein]-L-isoaspartate+S-adenosyl-L-methionine[protein]-L-isoaspartate alpha-methyl ester+S-adenosyl-L-homocysteine
Catalysed by PCMT1
Reaction pageLeft to rightBalance undeterminable
6 names
Resolves to: PCMT1