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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

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Atlas Graph Access Compounds Outcomes Proteins Interactions Papers Articles Pathways Processes Anatomy Cell types Organisms Materials Assessments

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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Reaction

4-methyl-2-oxopentanoate+proton+NADH(2-)2-hydroxy-4-methylvaleric acid+NAD(+)

Reversible · Balanced · EC 1.1.1.-

Compartment: GO:0005829

Inferred

Reference data, not a finding. Evidence key

Catalysts

DHRS2
HTATIP2
MDH1B
CBR4
CTBP1
BDH2
HSD11B1L
SDR9C7
SDR16C5
SDR42E2
SDR42E1
WWOX
AKR1C1
ADH5
AKR1B10
HSD17B11
HSD17B8
AKR1B15

Human-GEM MAR06925·2.0.1·CC BY 4.0Reference data