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Proteins/UNIPROT:O15118
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Mediates cholesterol transfer from lysosomes to endoplasmic reticulum by tethering endosomal/lysosomal compartments and endoplasmic reticulum membrane contact sites where it interacts with sterol transport protein GRAMD1B. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9..
(Microbial infection) Acts as an endosomal entry receptor for ebolavirus..
Function from UniProtKB (O15118), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 rows
462 statements
462 statements · 7 reference databases · Subject: NPC1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
3 reactions
Reaction pageReversibleBalancedcytosol, Golgi apparatus
Human-GEM MAR01916CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, lysosome
Human-GEM MAR01917CC BY 4.0Reference data
2 names
Resolves to: NPC1
Transported by NPC1 or STAR or NPC2 or PTCH1 or STARD3 or GRAMD1B or TMEM41B or PDZD8 or STARD4 or VMP1 or NPC1L1 or PTCH2
Reaction pageLeft to rightBalanced
Rhea RHEA:39747CC BY 4.0Reference data