3-iodo-L-tyrosine

Three steps

• all-trans-retinolReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by TPO, DIO1, DIO3, RETSATcytosol

• AH2Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
  3. A + NADH + H(+) = AH2 + NAD(+)

  Catalysed by TPO, DIO1, DIO3, AIFM1 and 1 morecytosolOne of 19 routes

• 5-aminolevulinic acidReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by IYD, AADAT, ALAS1, ALAS2 and 1 moremitochondrial matrix

• L-cysteineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 14 routes

• L-thyroxine sulfateReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by TPO, SULT1A3, SULT1A4, SULT1A1cytosol

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. Steryl-Sulfatase

  Catalysed by TPO, DIO1, DIO3, DIO2 and 1 morecytosol, Golgi apparatusOne of 5 routes

• glycine betaineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A12cytosol, extracellular spaceOne of 3 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by IYD, PAH, TPH1, TPH2

• CHEBI:17895Reach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 11 routes

• 3-phenylpyruvateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by IYD, PAH, GOT2, TATmitochondrial matrixOne of 5 routes

• CHEBI:18019Reach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 5 routes

• L-glutamineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by TPO, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 14 routes

• dTDPReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. pyruvate kinase (dTDP)

  Catalysed by TPO, SDS, SDSL, SRR and 2 morecytosol

• CHEBI:18095Reach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by TPO, SLC26A4cytosol, extracellular spaceOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by IYD, AADAT, GARTcytosol

• 2-phenylethylamineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by IYD, PAH, DDCcytosol

• ophthalmateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by IYD, AADAT, GSS

• S-methylmercury-L-cysteineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by IYD, PAH, SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by IYD, AADAT, AGXT2

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by IYD, AADAT, SHMT1cytosolOne of 2 routes

• 3-iodo-L-thyronineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by TPO, DIO1, DIO3, DIO2cytosol

• 3'-iodo-L-thyronineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by TPO, DIO1, DIO3, DIO2cytosol

• CHEBI:240943Reach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by TPO, SLC26A4, SLC6A5cytosol, extracellular spaceOne of 3 routes

• hypochlorous acidReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Peroxidase

  Catalysed by TPO, SLC26A4, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by TPO, SLC26A4, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 3 routes

• phenylacetylglycineReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by IYD, AADAT, GLYATcytosolOne of 3 routes

• 5(S)-HETEReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by TPO, SLCO1A2, SLCO1B3, GPX5 and 8 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:28666Reach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and LTD4 (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3, SLCO2A1cytosol, extracellular spaceOne of 5 routes

• a dicarboxylateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by IYD, PAH, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• K(+)Reach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by IYD, SLC7A13, SLC1A7, SLC1A3 and 3 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• Phe-tRNA(Phe)Reach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by IYD, PAH, FARSB, FARSAcytosol

• Gly-tRNA(Gly)Reach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by IYD, AADAT, GARS1cytosol

• Asp-tRNA(Asp)Reach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by IYD, SLC7A13, DARS1inner side of the membrane, outer side of the membrane, cytosol

• glycocholateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 7 routes

• cholateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• acetateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by TPO, SDS, SDSL, SRR and 5 morecytosol, extracellular spaceOne of 2 routes

• formic acidReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by TPO, SLC26A4cytosol, extracellular spaceOne of 4 routes

• propionic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by TPO, SDS, SDSL, SRR and 6 morecytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by TPO, SDS, SDSL, SRR and 6 morecytosol, extracellular spaceOne of 2 routes

• malonic acidReach from here →
  1. thyroid peroxidase (3-iodo-L-tyrosine)
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Malonate Transport, Antiport with Chloride

  Catalysed by TPO, SLC26A4cytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. L-Serine:pyruvate aminotransferase

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosolOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• N-carbamoyl-L-aspartateReach from here →
  1. iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by IYD, SLC7A13, CADinner side of the membrane, outer side of the membrane

• 3-oxopropanoateReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by TPO, SDS, SDSL, SRR and 1 morecytosol

• serotoninReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by TPO, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• D-serineReach from here →
  1. thyroid peroxidase (3,5-diiodo-L-tyrosine)
  2. 2-aminoacrylate aminohydrolase
  3. D-serine = pyruvate + NH4(+)

  Catalysed by TPO, SDS, SDSL, SRRcytosol