S-sulfanylglutathione

Three steps

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by ETHE1, SUOXmitochondrial matrix, cytosol

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. Persulfide dioxygenase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by ETHE1, SLC25A10, ASLmitochondrial matrix, cytosolOne of 2 routes

• L-dopaReach from here →
  1. Persulfide dioxygenase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. L-dopa + H(+) = dopamine + CO2

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, DDCmitochondrial matrix, extracellular space, cytosol

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Persulfide dioxygenase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by ETHE1, SLC25A10, ADSL, TNRC6Bmitochondrial matrix, cytosolOne of 2 routes

• L-histidineReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and histamine (cytosol to extracellular)
  3. L-histidine + H(+) = histamine + CO2

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, HDCmitochondrial matrix, extracellular space, cytosol

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by ETHE1, GOT2, GOT1mitochondrial matrix, cytosolOne of 5 routes

• 2-methyl-3-oxopropanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• L-methionineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 9 routes

• N-sulfo-D-glucosamineReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by ETHE1, SUOX, SGSHmitochondrial matrix, cytosol

• dehydroepiandrosterone 3-sulfateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by ETHE1, SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• L-tryptophanReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• L-alanineReach from here →
  1. Persulfide dioxygenase
  2. glutathione gamma-glutamylaminopeptidase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ETHE1, GGTLC3, GGT1, GGT5 and 3 moremitochondrial matrix, cytosolOne of 34 routes

• L-asparagineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by ETHE1, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 6 routes

• L,L-cystathionineReach from here →
  1. Persulfide dioxygenase
  2. Formation of Homocystine
  3. L-serine hydro-lyase (adding homocysteine

  Catalysed by ETHE1, CBSmitochondrial matrix, cytosol

• gamma-L-glutamyl-L-cysteineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by ETHE1, GCLC, GCLMmitochondrial matrix, cytosolOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. ATP:sulfate adenylyltransferase

  Catalysed by ETHE1, SUOX, PAPSS1, PAPSS2mitochondrial matrix, cytosolOne of 4 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by ETHE1, SQOR, PRODH2

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. Persulfide dioxygenase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by ETHE1, SLC25A10, ADSLmitochondrial matrix, cytosolOne of 2 routes

• S-sulfanyl-L-cysteineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by ETHE1, CARS2mitochondrial matrix, cytosol

• N(tau)-methylhistamineReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and histamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, HNMTmitochondrial matrix, extracellular space, cytosolOne of 3 routes

• (3S)-citramalyl-CoAReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by ETHE1, MPST, TST, CLYBLmitochondrial matrix, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ETHE1, MPST, TST, AGXT2mitochondrial matrix, cytosol

• hyodeoxycholateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and lithocholate (cytosol to extracellular)
  3. cytochrome P450 (lithocholate)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, CYP3A4mitochondrial matrix, extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine

  Catalysed by ETHE1, FAAH, PM20D1mitochondrial matrix, extracellular space, cytosol

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by ETHE1, PPCSmitochondrial matrix, cytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. Persulfide dioxygenase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, DBHmitochondrial matrix, extracellular space, cytosolOne of 20 routes

• L-prolineReach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by ETHE1, SQOR, PRODH, PRODH2

• estrone 3-sulfateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by ETHE1, SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

• 3-sulfino-L-alanineReach from here →
  1. Persulfide dioxygenase
  2. cystine to cysteine conversion
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by ETHE1, CDO1mitochondrial matrix, cytosolOne of 2 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ETHE1, MPST, TST, HOGA1mitochondrial matrix, cytosol

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. Persulfide dioxygenase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by ETHE1, SUOX, SLC4A1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• leukotriene D4Reach from here →
  1. Persulfide dioxygenase
  2. leukotriene C4 synthase (GSH)
  3. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by ETHE1, LTC4S, GGT1, GGT5mitochondrial matrix, cytosol

• 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. cytochrome P450 (arachidonate)

  Catalysed by ETHE1, CYP4F8mitochondrial matrix, extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• 3-demethylubiquinol-10Reach from here →
  1. Persulfide dioxygenase
  2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by ETHE1, SQOR, COQ3mitochondrial matrix

• (R)-adrenalineReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, PNMTmitochondrial matrix, extracellular space, cytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Persulfide dioxygenase
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by ETHE1, MPST, TST, HOGA1mitochondrial matrix, cytosol

• CHEBI:730073Reach from here →
  1. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by ETHE1, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• CHEBI:742324Reach from here →
  1. Persulfide dioxygenase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, COMT and 1 moremitochondrial matrix, extracellular space, cytosol

• (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by ETHE1, ALOX12Bmitochondrial matrix, extracellular space, cytosol

• (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. Arachidonate:oxygen 8-oxidoreductase

  Catalysed by ETHE1, ALOX12mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acid amide hydrolase (arachidonate)

  Catalysed by ETHE1, FAAHmitochondrial matrix, extracellular space, cytosol

• 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ETHE1, CYP2C9mitochondrial matrix, extracellular space, cytosol

• 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ETHE1, CYP1A1, CYP1A2, CYP2C9 and 2 moremitochondrial matrix, extracellular space, cytosol

• 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
  3. 10-HETE[n] + NAD+[n] = H+[n] + NADH[n] + 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate[n]

  Catalysed by ETHE1, SLCO2A1, ADH4mitochondrial matrix, extracellular space, cytosol, nucleusOne of 3 routes

• 7-oxolithocholateReach from here →
  1. Persulfide dioxygenase
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)

  Catalysed by ETHE1, SLCO1A2, SLCO1B3, HSD17B10mitochondrial matrix, extracellular space, cytosol

• (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by ETHE1, PTGS2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by ETHE1, PTGS2mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by ETHE1, PTGS2mitochondrial matrix, extracellular space, cytosol

• 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. Persulfide dioxygenase
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. Arachidonate: oxygen 11-oxidoreductase

  Catalysed by ETHE1, ALOX12mitochondrial matrix, extracellular space, cytosolOne of 2 routes