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(R)-adrenaline

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

16 compounds within 3 steps: 3 in 1, 2 in 2, 11 in 3

Does it reach a compound?

One step

(R)-3,4-dihydroxymandelaldehydeReach from here →
1. (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
Catalysed by MAOA, MAOB
(R)-adrenaline 4'-O-sulfateReach from here →
1. (R)-adrenaline + 3'-phosphoadenylyl sulfate = (R)-adrenaline 4'-O-sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by SULT1A3, SULT1A4
methylamineReach from here →
1. (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
Catalysed by MAOA, MAOB

Two steps

formaldehydeReach from here →
1. (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
2. methylamine:oxygen oxidoreductase (deaminating) (copper-containing)
Catalysed by MAOA, MAOB, AOC2, AOC1 and 1 morecytosolOne of 2 routes
(R)-noradrenalineReach from here →
1. (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
2. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
Catalysed by MAOA, MAOB

Three steps

2,4-dinitrophenyl-S-glutathioneReach from here →
Catalysed by MAOA, MAOB, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes
formateReach from here →

Catalysed by MAOA, MAOB, AOC2, AOC1 and 2 morecytosol

methanethiolReach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
methylamine:oxygen oxidoreductase (deaminating) (copper-containing)
methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

Catalysed by MAOA, MAOB, AOC2, AOC1 and 2 morecytosol

CHEBI:16856Reach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
transport of GSH and noradrenaline (cytosol to extracellular)

Catalysed by MAOA, MAOB, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

CHEBI:17724Reach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
methylamine:oxygen oxidoreductase (deaminating) (copper-containing)
dimethylglycine dehydrogenase (formaldehyde)

Catalysed by MAOA, MAOB, AOC2, AOC1 and 3 morecytosol

(R)-normetanephrineReach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
S-Adenosyl-L-methionine:catechol O-methyltransferase

Catalysed by MAOA, MAOB, COMT, LRTOMTcytosol

(6R)-5,10-methylenetetrahydrofolic acidReach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
methylamine:oxygen oxidoreductase (deaminating) (copper-containing)
formaldehyde to 5,10-methylene-THF conversion

Catalysed by MAOA, MAOB, AOC2, AOC1 and 1 morecytosol

(R)-noradrenaline 4'-O-sulfateReach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
sulfotransferase (noradrenaline)

Catalysed by MAOA, MAOB, SULT1A3cytosolOne of 2 routes

CHEBI:28918Reach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)
S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

Catalysed by MAOA, MAOB, PNMTcytosol

sarcosineReach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
methylamine:oxygen oxidoreductase (deaminating) (copper-containing)
sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

Catalysed by MAOA, MAOB, AOC2, AOC1 and 2 morecytosol

S-formylglutathioneReach from here →

(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
methylamine:oxygen oxidoreductase (deaminating) (copper-containing)
alcohol dehydrogenase (formaldehyde)

Catalysed by MAOA, MAOB, AOC2, AOC1 and 7 morecytosol