7-oxolithocholate

1. chenodeoxycholate + NADP(+) = 7-oxolithocholate + NADPH + H(+)

Catalysed by HSD11B1

1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)

Catalysed by HSD11B1

1. chenodeoxycholate + NADP(+) = 7-oxolithocholate + NADPH + H(+)
2. Chenodeoxycholic acid 6alpha-hydroxylase

Catalysed by HSD11B1, CYP3A4cytosol

1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by HSD11B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. chenodeoxycholate + NADP(+) = 7-oxolithocholate + NADPH + H(+)
2. chenodeoxycholate:CoA ligase (AMP-forming)
3. bile acid-CoA: amino acid N-acyltransferase

Catalysed by HSD11B1, SLC27A5, BAATcytosol, peroxisomeOne of 8 routes

1. 7-oxolithocholate + NADPH + H(+) = ursodeoxycholate + NADP(+)
2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
3. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)

Catalysed by