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Proteins/UNIPROT:P08319
Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Also catalyzes the reduction of benzoquinones..
Function from UniProtKB (P08319), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · metabolized by
2 compounds
2 compounds.
0 reported routes2 assembled routes
50 statements
50 statements · 8 reference databases · Subject: ADH4 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
31 reactions
5 names
Resolves to: ADH4
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.2, 1.1.1.21, 1.1.1.72mitochondrial matrix
Human-GEM MAR00458CC BY 4.0Reference data
MAM00599c+NAD(+)MAM00600c+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR01129CC BY 4.0Reference data
MAM00599m+NAD(+)MAM00600m+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1mitochondrial matrix
Human-GEM MAR01130CC BY 4.0Reference data
MAM00599r+NAD(+)MAM00600r+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1endoplasmic reticulum
Human-GEM MAR01131CC BY 4.0Reference data
MAM00596x+NAD(+)MAM00601x+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1peroxisome
Human-GEM MAR01288CC BY 4.0Reference data
MAM00756c+proton+NADH(2-)MAM01093c+NAD(+)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR01684CC BY 4.0Reference data
ethanol+NAD(+)acetaldehyde+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.71cytosol
Human-GEM MAR03905CC BY 4.0Reference data
methanol+NAD(+)formaldehyde+proton+NADH(2-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.244cytosol
Human-GEM MAR04202CC BY 4.0Reference data
(5-hydroxyindol-3-yl)acetaldehyde+proton+NADPH(4-)MAM01110c+NADP(3-)
Catalysed by ADHFE1 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageReversibleBalancedEC 1.1.1.1cytosol
Human-GEM MAR04561CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105cytosol
Human-GEM MAR06631CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105endoplasmic reticulum
Human-GEM MAR06633CC BY 4.0Reference data